Lumbar drainage for the treatment of refractory intracranial hypertension in HIV-negative cryptococcal meningitis

Qilong Zhang, Hang Li, Keming Zhang, Amir Arastehfar, Farnaz Daneshnia, Wenjie Fang, Peijuan He, Weifeng Kuang, Guoqiang Jiang, Min Chen, Teun Boekhout, Shuai Li, Weiwei Jiang, Wanqing Liao, Weihua Pan

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

Aim: This study aims to evaluate lumbar drainage (LD) for controlling refractory intracranial hypertension among non-HIV cryptococcal meningitis patients. Patients & methods: A case-control study was designed to compare LD (case) with repeated lumbar puncture (control). Results: Both LD and repeated lumbar puncture can efficiently control refractory intracranial hypertension. LD group showed better clinical symptom remission, such as lower rate of headache, vision disorders, signs of meningeal irritation and conscious disturbance, than control group. LD group was reported with higher intracranial pressure reduction (173.75 ± 17.72 mmH2O) than those among control group (113.50 ± 14.94 mmH2O; p < 0.05). Conclusion: LD is an effective and safe alternative to control refractory intracranial hypertension in HIV-negative cryptococcal meningitis patients.

Originele taal-2Engels
Pagina's (van-tot)859-866
Aantal pagina's8
TijdschriftFuture Microbiology
Volume14
DOI's
StatusGepubliceerd - jul 2019

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