Lymphatic vascular morphogenesis in development, physiology, and disease

S. Schulte-Merker; A. Sabine; T.V. Petrova

doi:10.1083/jcb.201012094

Lymphatic vascular morphogenesis in development, physiology, and disease

S. Schulte-Merker, A. Sabine, T.V. Petrova

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases. [KEYWORDS: Animals, Biological Transport, Gene Expression Regulation, Hematopoietic Stem Cells/metabolism, Homeostasis, Humans, Lymph/metabolism, Lymphangiogenesis/genetics, Lymphatic Vessels/embryology/metabolism/ physiopathology, Lymphedema/genetics/metabolism/ physiopathology, Morphogenesis]

Originele taal-2	Engels
Pagina's (van-tot)	607-618
Tijdschrift	Journal of Cell Biology
Volume	193
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1083/jcb.201012094
Status	Gepubliceerd - 2011

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(c) KNAW - Koninklijke Nederlandse Akademie van Wetenschappen, 2011
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author = "S. Schulte-Merker and A. Sabine and T.V. Petrova",

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AB - The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases. [KEYWORDS: Animals, Biological Transport, Gene Expression Regulation, Hematopoietic Stem Cells/metabolism, Homeostasis, Humans, Lymph/metabolism, Lymphangiogenesis/genetics, Lymphatic Vessels/embryology/metabolism/ physiopathology, Lymphedema/genetics/metabolism/ physiopathology, Morphogenesis]

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Lymphatic vascular morphogenesis in development, physiology, and disease

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