TY - JOUR
T1 - Many parasitoids lack adult fat accumulation, despite fatty acid synthesis
T2 - A discussion of concepts and considerations for future research
AU - Visser, Bertanne
AU - Le Lann, Cécile
AU - Hahn, Daniel A.
AU - Lammers, Mark
AU - Nieberding, Caroline M.
AU - Alborn, Hans T.
AU - Enriquez, Thomas
AU - Scheifler, Mathilde
AU - Harvey, Jeffrey A.
AU - Ellers, Jacintha
N1 - data archiving: No data
PY - 2023/4/10
Y1 - 2023/4/10
N2 - Fat reserves, specifically the accumulation of triacylglycerols, are a major energy source and play a key role for life histories. Fat accumulation is a conserved metabolic pattern across most insects, yet in most parasitoid species adults do not gain fat mass, even when nutrients are readily available and provided ad libitum. This extraordinary physiological phenotype has evolved repeatedly in phylogenetically dispersed parasitoid species. This poses a conundrum because it could lead to significant constraints on energy allocation toward key adult functions such as survival and reproduction. Recent work on the underlying genetic and biochemical mechanisms has spurred a debate on fat accumulation versus fat production, because of incongruent interpretation of results obtained using different methodologies. This debate is in part due to semantics, highlighting the need for a synthetic perspective on fat accumulation that reconciles previous debates and provides new insights and terminology. In this paper, we propose updated, unambiguous terminology for future research in the field, including “fatty acid synthesis” and “lack of adult fat accumulation”, and describe the distinct metabolic pathways involved in the complex process of lipogenesis. We then discuss the benefits and drawbacks of the main methods available to measure fatty acid synthesis and adult fat accumulation. Most importantly, gravimetric/colorimetric and isotope tracking methods give complementary information, provided that they are applied with appropriate controls and interpreted correctly. We also compiled a comprehensive list of fat accumulation studies performed during the last 25 years. We present avenues for future research that combine chemistry, ecology, and evolution into an integrative approach, which we think is needed to understand the dynamics of fat accumulation in parasitoids.
AB - Fat reserves, specifically the accumulation of triacylglycerols, are a major energy source and play a key role for life histories. Fat accumulation is a conserved metabolic pattern across most insects, yet in most parasitoid species adults do not gain fat mass, even when nutrients are readily available and provided ad libitum. This extraordinary physiological phenotype has evolved repeatedly in phylogenetically dispersed parasitoid species. This poses a conundrum because it could lead to significant constraints on energy allocation toward key adult functions such as survival and reproduction. Recent work on the underlying genetic and biochemical mechanisms has spurred a debate on fat accumulation versus fat production, because of incongruent interpretation of results obtained using different methodologies. This debate is in part due to semantics, highlighting the need for a synthetic perspective on fat accumulation that reconciles previous debates and provides new insights and terminology. In this paper, we propose updated, unambiguous terminology for future research in the field, including “fatty acid synthesis” and “lack of adult fat accumulation”, and describe the distinct metabolic pathways involved in the complex process of lipogenesis. We then discuss the benefits and drawbacks of the main methods available to measure fatty acid synthesis and adult fat accumulation. Most importantly, gravimetric/colorimetric and isotope tracking methods give complementary information, provided that they are applied with appropriate controls and interpreted correctly. We also compiled a comprehensive list of fat accumulation studies performed during the last 25 years. We present avenues for future research that combine chemistry, ecology, and evolution into an integrative approach, which we think is needed to understand the dynamics of fat accumulation in parasitoids.
KW - Hymenoptera
KW - Life histories
KW - Lipids
KW - Lipogenesis
KW - Nutrient metabolism
KW - Parasitic wasp
U2 - 10.1016/j.cris.2023.100055
DO - 10.1016/j.cris.2023.100055
M3 - Book/Film/Article review
AN - SCOPUS:85151877085
SN - 2666-5158
VL - 3
JO - Current Research in Insect Science
JF - Current Research in Insect Science
M1 - 100055
ER -