Mechanisms underlying vestibulo-cerebellar motor learning in mice depend on movement direction

TY - JOUR

T1 - Mechanisms underlying vestibulo-cerebellar motor learning in mice depend on movement direction

AU - Voges, Kai

AU - Wu, Bin

AU - Post, Laura

AU - Schonewille, Martijn

AU - De Zeeuw, Chris I

N1 - This article is protected by copyright. All rights reserved.

PY - 2017

Y1 - 2017

N2 - Compensatory eye movements elicited by head rotation, also known as vestibulo-ocular reflex (VOR), can be adapted with the use of visual feedback. The cerebellum is essential for this type of movement adaptation, but its neuronal correlates remain to be elucidated. Here we show that the direction of vestibular input determines the magnitude of eye movement adaptation induced by mismatched visual input in mice, with larger changes during contraversive head rotation. Moreover, the location of the neural correlate of this changed behaviour depends on the type of paradigm. Gain-increase paradigms induce increased simple spike (SS) activity in ipsilateral cerebellar Purkinje cells (PC), which is in line with eye movements triggered by optogenetic PC activation. In contrast, gain-decrease paradigms do not induce changes in SS activity, highlighting that the murine vestibulo-cerebellar cortical circuitry is optimally designed to enhance ipsiversive eye movements. This article is protected by copyright. All rights reserved.

AB - Compensatory eye movements elicited by head rotation, also known as vestibulo-ocular reflex (VOR), can be adapted with the use of visual feedback. The cerebellum is essential for this type of movement adaptation, but its neuronal correlates remain to be elucidated. Here we show that the direction of vestibular input determines the magnitude of eye movement adaptation induced by mismatched visual input in mice, with larger changes during contraversive head rotation. Moreover, the location of the neural correlate of this changed behaviour depends on the type of paradigm. Gain-increase paradigms induce increased simple spike (SS) activity in ipsilateral cerebellar Purkinje cells (PC), which is in line with eye movements triggered by optogenetic PC activation. In contrast, gain-decrease paradigms do not induce changes in SS activity, highlighting that the murine vestibulo-cerebellar cortical circuitry is optimally designed to enhance ipsiversive eye movements. This article is protected by copyright. All rights reserved.

KW - Journal Article

U2 - 10.1113/JP274346

DO - 10.1113/JP274346

M3 - Article

C2 - 28586131

SN - 0022-3751

VL - 595

SP - 5301

EP - 5326

JO - The Journal of physiology

JF - The Journal of physiology

ER -