Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila

Angelica Aguilera-Gomez, Catherine Rabouille

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.

Originele taal-2Engels
Pagina's (van-tot)310-317
Aantal pagina's8
TijdschriftDevelopmental Biology
Volume428
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - 15 aug 2017

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