Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila

TY - JOUR

T1 - Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila

AU - Aguilera-Gomez, Angelica

AU - Rabouille, Catherine

N1 - Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2017/8/15

Y1 - 2017/8/15

N2 - Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.

AB - Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.

KW - Animals

KW - Cell Compartmentation

KW - Drosophila Proteins

KW - Drosophila melanogaster

KW - Female

KW - Genes, Insect

KW - Membranes

KW - Metabolic Networks and Pathways

KW - Models, Biological

KW - Oocytes

KW - Organelles

KW - SEC Translocation Channels

KW - Transforming Growth Factor alpha

KW - Journal Article

KW - Review

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ydbio.2017.03.029

DO - 10.1016/j.ydbio.2017.03.029

M3 - Article

C2 - 28377034

SN - 0012-1606

VL - 428

SP - 310

EP - 317

JO - Developmental Biology

JF - Developmental Biology

IS - 2

ER -