Meningitis caused by Filobasidium uniguttulatum: case report and overview of the literature

TY - JOUR

T1 - Meningitis caused by Filobasidium uniguttulatum: case report and overview of the literature

AU - Pan, W.

AU - Liao, W.

AU - Hagen, F.

AU - Theelen, B.J.F.

AU - Geertsen, E.

AU - Shi, W.

AU - Meis, J.F.

AU - Boekhout, T.

N1 - Reporting year: 2011 Metis note: Dit is een publicatie uit 2012 maar was al opgegeven voor het verslagjaar 2011 [A.Guicherit]

PY - 2012

Y1 - 2012

N2 - Cryptococcal meningitis is mainly caused by Cryptococcus neoformans and Cryptococcus gattii, but occasionally other Cryptococcus species and phylogenetically related species are involved. Herein, we present a case of cryptococcal meningitis from China, which was caused by an azole and flucytosine resistant Filobasidium uniguttulatum. In addition, we present an overview of the literature of meningitis caused by Cryptococcus species other than C. neoformans and C. gattii. Eight cases were related to infections of the central nervous system. Leukaemia and cancer were important risk factors in HIV-negative patients. Molecular identification and susceptibility testing are important for proper management of patients because the species involved may differ in susceptibility to antifungal drugs. Keywords: Cryptococcus; Filobasidium uniguttulatum; identification; meningitis; treatment

AB - Cryptococcal meningitis is mainly caused by Cryptococcus neoformans and Cryptococcus gattii, but occasionally other Cryptococcus species and phylogenetically related species are involved. Herein, we present a case of cryptococcal meningitis from China, which was caused by an azole and flucytosine resistant Filobasidium uniguttulatum. In addition, we present an overview of the literature of meningitis caused by Cryptococcus species other than C. neoformans and C. gattii. Eight cases were related to infections of the central nervous system. Leukaemia and cancer were important risk factors in HIV-negative patients. Molecular identification and susceptibility testing are important for proper management of patients because the species involved may differ in susceptibility to antifungal drugs. Keywords: Cryptococcus; Filobasidium uniguttulatum; identification; meningitis; treatment

U2 - 10.1111/j.1439-0507.2011.02054.x

DO - 10.1111/j.1439-0507.2011.02054.x

M3 - Article

SN - 0933-7407

VL - 55

SP - 105

EP - 109

JO - Mycoses

JF - Mycoses

IS - 2

ER -