Metabolomics: the chemistry between ecology and genetics

TY - JOUR

T1 - Metabolomics: the chemistry between ecology and genetics

AU - Macel, M.

AU - Van Dam, N.M.

AU - Keurentjes, J.J.B.

N1 - Reporting year: 2010 Metis note: 4723;CTE; TE; file:///L:\EndnoteDatabases\NIOOPUB\pdfs\PDFS2010\Macel_ea_4723.pdf

PY - 2010

Y1 - 2010

N2 - Metabolomics is a fast developing field of comprehensive untargeted chemical analyses. It has many applications and can in principle be used on any organism without prior knowledge of the metabolome or genome. The amount of functional information that is acquired with metabolomics largely depends on whether a metabolome database has been developed for the focal species. Metabolomics is a level downstream from transcriptomics and proteomics and has been widely advertised as a functional genomics and systems biology tool. Indeed, it has been successfully applied to link phenotypes to genotypes in the model plant Arabidopsis thaliana. Metabolomics is also increasingly being used in ecology (ecological metabolomics) and environmental sciences (environmental metabolomics). In ecology, the technique has led to novel insights into the mechanisms of plant resistance to herbivores. Some of the most commonly used analytical metabolomic platforms are briefly discussed in this review, as well as their limitations. We will mainly focus on the application of metabolomics in plant ecology and genetics.

AB - Metabolomics is a fast developing field of comprehensive untargeted chemical analyses. It has many applications and can in principle be used on any organism without prior knowledge of the metabolome or genome. The amount of functional information that is acquired with metabolomics largely depends on whether a metabolome database has been developed for the focal species. Metabolomics is a level downstream from transcriptomics and proteomics and has been widely advertised as a functional genomics and systems biology tool. Indeed, it has been successfully applied to link phenotypes to genotypes in the model plant Arabidopsis thaliana. Metabolomics is also increasingly being used in ecology (ecological metabolomics) and environmental sciences (environmental metabolomics). In ecology, the technique has led to novel insights into the mechanisms of plant resistance to herbivores. Some of the most commonly used analytical metabolomic platforms are briefly discussed in this review, as well as their limitations. We will mainly focus on the application of metabolomics in plant ecology and genetics.

U2 - 10.1111/j.1755-0998.2010.02854.x

DO - 10.1111/j.1755-0998.2010.02854.x

M3 - Article

SN - 1755-098X

VL - 10

SP - 583

EP - 593

JO - Molecular Ecology Resources

JF - Molecular Ecology Resources

IS - 4

ER -