TY - JOUR
T1 - Multisensory task demands temporally extend the causal requirement for visual cortex in perception
AU - Oude Lohuis, Matthijs N
AU - Pie, Jean L
AU - Marchesi, Pietro
AU - Montijn, Jorrit S
AU - de Kock, Christiaan P J
AU - Pennartz, Cyriel M A
AU - Olcese, Umberto
N1 - © 2022. The Author(s).
PY - 2022/5/23
Y1 - 2022/5/23
N2 - Primary sensory areas constitute crucial nodes during perceptual decision making. However, it remains unclear to what extent they mainly constitute a feedforward processing step, or rather are continuously involved in a recurrent network together with higher-order areas. We found that the temporal window in which primary visual cortex is required for the detection of identical visual stimuli was extended when task demands were increased via an additional sensory modality that had to be monitored. Late-onset optogenetic inactivation preserved bottom-up, early-onset responses which faithfully encoded stimulus features, and was effective in impairing detection only if it preceded a late, report-related phase of the cortical response. Increasing task demands were marked by longer reaction times and the effect of late optogenetic inactivation scaled with reaction time. Thus, independently of visual stimulus complexity, multisensory task demands determine the temporal requirement for ongoing sensory-related activity in V1, which overlaps with report-related activity.
AB - Primary sensory areas constitute crucial nodes during perceptual decision making. However, it remains unclear to what extent they mainly constitute a feedforward processing step, or rather are continuously involved in a recurrent network together with higher-order areas. We found that the temporal window in which primary visual cortex is required for the detection of identical visual stimuli was extended when task demands were increased via an additional sensory modality that had to be monitored. Late-onset optogenetic inactivation preserved bottom-up, early-onset responses which faithfully encoded stimulus features, and was effective in impairing detection only if it preceded a late, report-related phase of the cortical response. Increasing task demands were marked by longer reaction times and the effect of late optogenetic inactivation scaled with reaction time. Thus, independently of visual stimulus complexity, multisensory task demands determine the temporal requirement for ongoing sensory-related activity in V1, which overlaps with report-related activity.
U2 - 10.1038/s41467-022-30600-4
DO - 10.1038/s41467-022-30600-4
M3 - Article
C2 - 35606448
SN - 2041-1723
VL - 13
SP - 2864
JO - Nature Communications
JF - Nature Communications
IS - 1
ER -