Mutant PTEN in Cancer: Worse Than Nothing

TY - JOUR

T1 - Mutant PTEN in Cancer

T2 - Worse Than Nothing

AU - Leslie, Nick R

AU - den Hertog, Jeroen

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/4/24

Y1 - 2014/4/24

N2 - Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.

AB - Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.

KW - Animals

KW - Female

KW - Humans

KW - Male

KW - PTEN Phosphohydrolase

KW - Signal Transduction

U2 - 10.1016/j.cell.2014.04.008

DO - 10.1016/j.cell.2014.04.008

M3 - Article

C2 - 24766800

SN - 0092-8674

VL - 157

SP - 527

EP - 529

JO - Cell

JF - Cell

IS - 3

ER -