No link of serotonin 2C receptor editing to serotonin transporter genotype

R. Lyddon, E. Cuppen, V. Haroutunian, L.J. Siever, S. Dracheva

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

RNA editing is a post-transcriptional process, which has the potential to alter the function of encoded proteins. In particular, serotonin 2C receptor (5-HT2cR) mRNA editing can produce 24 protein isoforms of varying functionality. Rodent studies have shown that 5-HT2cR editing is dynamically modulated in response to environmental challenges. Basal extracellular serotonin, which is strongly influenced by serotonin transporter (SERT), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. Here, 5-HT2cR editing is evaluated in SERT mutant versus wild-type rats, and in humans with different SERT genotypes. Our findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels.
Originele taal-2Engels
Pagina's (van-tot)1080-1084
TijdschriftNeuroReport
Volume21
Nummer van het tijdschrift17
DOI's
StatusGepubliceerd - 2010

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