TY - JOUR
T1 - Not all bones are created equal - using zebrafish and other teleost species in osteogenesis research
AU - Apschner, A.
AU - Schulte-Merker, S.
AU - Witten, P.E.
N1 - Reporting year: 2011
PY - 2011
Y1 - 2011
N2 - Developmental osteogenesis and pathologies of mineralized tissues are areas of intense investigations in the mammalian field, but different from other areas of organ formation and developmental biology, zebrafish have been somewhat slow in joining the area of bone research. In recent years, however, genetic screens have provided a number of exciting mutants, and transgenic lines have been developed that permit visualization of osteoblasts and osteoclasts in vivo. We here review some of the recent literature and provide examples where insights from studies in zebrafish have complemented the information available from mammalian models or clinical studies. Furthermore, we provide a comparative overview about different forms of bone within the teleost lineage, and between teleosts and mammals.
AB - Developmental osteogenesis and pathologies of mineralized tissues are areas of intense investigations in the mammalian field, but different from other areas of organ formation and developmental biology, zebrafish have been somewhat slow in joining the area of bone research. In recent years, however, genetic screens have provided a number of exciting mutants, and transgenic lines have been developed that permit visualization of osteoblasts and osteoclasts in vivo. We here review some of the recent literature and provide examples where insights from studies in zebrafish have complemented the information available from mammalian models or clinical studies. Furthermore, we provide a comparative overview about different forms of bone within the teleost lineage, and between teleosts and mammals.
U2 - 10.1016/B978-0-12-381320-6.00010-2
DO - 10.1016/B978-0-12-381320-6.00010-2
M3 - Article
SN - 0091-679X
VL - 105
SP - 239
EP - 255
JO - Methods in Cell Biology
JF - Methods in Cell Biology
ER -