Samenvatting
The small GTPase Arf1 that is classically required for the budding of COPI-coated vesicles from the Golgi membrane is now proposed to have novel and conserved roles in the morphological and functional maintenance of mitochondria: It functionally localizes to ER/mitochondria contact sites; it allows for the recruitment of a degradation machinery to mitochondria to remove toxic mitofusin/Fzo1 clusters; and it allows the extension of autophagy sequestration membranes needed for mitophagy to clear damaged mitochondria.
Originele taal-2 | Engels |
---|---|
Pagina's (van-tot) | 2604-5 |
Aantal pagina's | 2 |
Tijdschrift | EMBO Journal |
Volume | 33 |
Nummer van het tijdschrift | 22 |
DOI's | |
Status | Gepubliceerd - 18 nov. 2014 |