Old dog, new tricks: Arf1 required for mitochondria homeostasis

TY - JOUR

T1 - Old dog, new tricks

T2 - Arf1 required for mitochondria homeostasis

AU - Rabouille, Catherine

PY - 2014/11/18

Y1 - 2014/11/18

N2 - The small GTPase Arf1 that is classically required for the budding of COPI-coated vesicles from the Golgi membrane is now proposed to have novel and conserved roles in the morphological and functional maintenance of mitochondria: It functionally localizes to ER/mitochondria contact sites; it allows for the recruitment of a degradation machinery to mitochondria to remove toxic mitofusin/Fzo1 clusters; and it allows the extension of autophagy sequestration membranes needed for mitophagy to clear damaged mitochondria.

AB - The small GTPase Arf1 that is classically required for the budding of COPI-coated vesicles from the Golgi membrane is now proposed to have novel and conserved roles in the morphological and functional maintenance of mitochondria: It functionally localizes to ER/mitochondria contact sites; it allows for the recruitment of a degradation machinery to mitochondria to remove toxic mitofusin/Fzo1 clusters; and it allows the extension of autophagy sequestration membranes needed for mitophagy to clear damaged mitochondria.

U2 - 10.15252/embj.201489899

DO - 10.15252/embj.201489899

M3 - Article

C2 - 25230932

SN - 0261-4189

VL - 33

SP - 2604

EP - 2605

JO - EMBO Journal

JF - EMBO Journal

IS - 22

ER -