TY - JOUR
T1 - Paracoccidioides and Paracoccidioidomycosis in the 21st Century
AU - Rodrigues, Anderson Messias
AU - Hagen, Ferry
AU - Puccia, Rosana
AU - Hahn, Rosane Christine
AU - de Camargo, Zoilo Pires
N1 - © 2023. The Author(s), under exclusive licence to Springer Nature B.V.
PY - 2023/4
Y1 - 2023/4
N2 - Paracoccidioidomycosis (PCM) defines a broad spectrum of human and animal diseases caused by Paracoccidioides species (Onygenales). In the twenty-first century, Paracoccidioides advanced from a monotypic taxon to a genus that harbors seven species, including P. brasiliensis sensu stricto, P. americana, P. restrepiensis, P. venezuelensis, P. lutzii, P. loboi, and P. cetii. Classic PCM, acquired upon inhalation of propagules from P. brasiliensis sensu stricto, P. americana, P. restrepiensis, P. venezuelensis, and P. lutzii, affects the human lungs and may progress to systemic granulomatous disease with tegumentary and visceral involvement. On the other hand, PCM loboi and PCM ceti caused by the unculturable P. loboi and P. cetii are subcutaneous mycoses, typically observed as keloid lesions in humans and dolphins. Such heterogeneity highlights the importance of recognizing species boundaries in Paracoccidioides to gain insights into the ecology, evolution, clinical features, and mitigation strategies to tackle the advance of PCM.
AB - Paracoccidioidomycosis (PCM) defines a broad spectrum of human and animal diseases caused by Paracoccidioides species (Onygenales). In the twenty-first century, Paracoccidioides advanced from a monotypic taxon to a genus that harbors seven species, including P. brasiliensis sensu stricto, P. americana, P. restrepiensis, P. venezuelensis, P. lutzii, P. loboi, and P. cetii. Classic PCM, acquired upon inhalation of propagules from P. brasiliensis sensu stricto, P. americana, P. restrepiensis, P. venezuelensis, and P. lutzii, affects the human lungs and may progress to systemic granulomatous disease with tegumentary and visceral involvement. On the other hand, PCM loboi and PCM ceti caused by the unculturable P. loboi and P. cetii are subcutaneous mycoses, typically observed as keloid lesions in humans and dolphins. Such heterogeneity highlights the importance of recognizing species boundaries in Paracoccidioides to gain insights into the ecology, evolution, clinical features, and mitigation strategies to tackle the advance of PCM.
KW - Animals
KW - Humans
KW - Dolphins/microbiology
KW - Genomics
KW - Paracoccidioides/classification
KW - Paracoccidioidomycosis/diagnosis
KW - Phylogeny
U2 - 10.1007/s11046-022-00704-y
DO - 10.1007/s11046-022-00704-y
M3 - Book/Film/Article review
C2 - 36633737
SN - 0301-486X
VL - 188
SP - 129
EP - 133
JO - Mycopathologia
JF - Mycopathologia
IS - 1-2
ER -