Phialemoniopsis limonesiae sp. nov. causing cutaneous phaeohyphomycosis in an immunosuppressed woman

TY - JOUR

T1 - Phialemoniopsis limonesiae sp. nov. causing cutaneous phaeohyphomycosis in an immunosuppressed woman

AU - Martinez, D. Alvarez

AU - Alberto, C.

AU - Riat, A.

AU - Schuhler, C.

AU - Valladares, P.

AU - Ninet, B.

AU - Kraak, B.

AU - Crous, P. W.

AU - Hou, L. W.

AU - Trellu, L. Toutous

N1 - PMID: 33634736

PY - 2021/3

Y1 - 2021/3

N2 - Rare or opportunistic fungal infections are mostly described in immunosuppressed patients. We present a case of a cutaneous phaeohyphomycosis that developed on the dorsal foot in an immunosuppressed woman suffering from AIDS, caused by a novel Phialemoniopsis species. It clinically presented as an indurated violaceous plaque, surmounted by nodules exuding a sero-purulent discharge. A filamentous fungus was isolated from pus and cutaneous biopsy. ITS and LSU sequences phylogenetically resolved the fungus as an unknown species of Phialemoniopsis, which is an unresolved family within Sordariomycetes. In this study we describe the new species as Phialemoniopsis limonesiae, which clusters on a single branch clearly separated from its closest phylogenetic neighbours. This new strain showed low MIC to itraconazole, voriconazole and posaconazole.

AB - Rare or opportunistic fungal infections are mostly described in immunosuppressed patients. We present a case of a cutaneous phaeohyphomycosis that developed on the dorsal foot in an immunosuppressed woman suffering from AIDS, caused by a novel Phialemoniopsis species. It clinically presented as an indurated violaceous plaque, surmounted by nodules exuding a sero-purulent discharge. A filamentous fungus was isolated from pus and cutaneous biopsy. ITS and LSU sequences phylogenetically resolved the fungus as an unknown species of Phialemoniopsis, which is an unresolved family within Sordariomycetes. In this study we describe the new species as Phialemoniopsis limonesiae, which clusters on a single branch clearly separated from its closest phylogenetic neighbours. This new strain showed low MIC to itraconazole, voriconazole and posaconazole.

KW - Bioavailability itraconazole

KW - deep cutaneous phaeohyphomycosis

KW - immunosuppression

KW - opportunistic fungal infections

KW - a new taxon

U2 - 10.1080/22221751.2021.1892458

DO - 10.1080/22221751.2021.1892458

M3 - Article

SN - 2222-1751

VL - 10

SP - 400

EP - 406

JO - Emerging Microbes and Infections

JF - Emerging Microbes and Infections

IS - 1

ER -