Phylogenetic diversity of human pathogenic Fusarium and emergence of uncommon virulent species

Husam Salah, Abdullah M S Al-Hatmi, Bart Theelen, Mohammed Abukamar, Samar Hashim, Anne D van Diepeningen, Cornelia Lass-Florl, Teun Boekhout, Muna Almaslamani, Saad J Taj-Aldeen

    Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

    38 Citaten (Scopus)

    Samenvatting

    OBJECTIVES: Fusarium species cause a broad spectrum of infections. However, little is known about the etiological agents to the species level. We identified Fusarium species isolated from clinical specimens including those of high risk patients to better understand the species involved in the pathogenesis.

    METHODS: A set of 44 Fusarium isolates were identified by two-locus sequence typing using partial sequences of the second largest subunit of RNA polymerase (RPB2) and translation elongation factor 1 alpha (TEF-1α).

    RESULTS: The identified species belonged to four species complexes (SC); the most common SC was Fusarium solani (FSSC) (75%), followed by Fusarium oxysporum (FOSC) (4.5%), Fusarium fujikuroi (FFSC) (13.6%), and Fusarium dimerum (FDSC) (6.8%). Sites of infections were nails (n = 19, 43.2%), skin (n = 7, 15.9%), cornea (n = 6, 13.6%), blood (n = 3, 9%), wound (n = 4, 6.8%), burn (n = 2, 4.5%), tissue (n = 2, 4.5%), and urine (n = 1, 2.27%). Fusarium acutatum was rare and seem restricted to the Middle East. Comorbidities associated with invasive infections were hematological malignancy and autoimmune disorders.

    CONCLUSIONS: Members of the FSSC predominantly caused cornea, nail and bloodstream infections. Less frequently encountered were the FOSC, FFSC and FDSC. More accurate molecular identification of Fusarium species is important to predict therapeutic outcome and the emergence of these species.

    Originele taal-2Engels
    Pagina's (van-tot)658-66
    Aantal pagina's9
    TijdschriftThe Journal of infection
    Volume71
    Nummer van het tijdschrift6
    DOI's
    StatusGepubliceerd - dec. 2015

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