Plasticity mechanisms of genetically distinct Purkinje cells

Stijn Voerman; Robin Broersen; Sigrid M A Swagemakers; Chris I De Zeeuw; Peter J van der Spek

doi:10.1002/bies.202400008

Plasticity mechanisms of genetically distinct Purkinje cells

Stijn Voerman, Robin Broersen, Sigrid M A Swagemakers, Chris I De Zeeuw, Peter J van der Spek

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.

Originele taal-2	Engels
Pagina's (van-tot)	e2400008
Tijdschrift	BioEssays
Volume	46
DOI's	https://doi.org/10.1002/bies.202400008
Status	Gepubliceerd - 02 mei 2024

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title = "Plasticity mechanisms of genetically distinct Purkinje cells",

abstract = "Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.",

author = "Stijn Voerman and Robin Broersen and Swagemakers, {Sigrid M A} and {De Zeeuw}, {Chris I} and {van der Spek}, {Peter J}",

note = "{\textcopyright} 2024 The Authors. BioEssays published by Wiley Periodicals LLC.",

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AU - Voerman, Stijn

AU - Broersen, Robin

AU - Swagemakers, Sigrid M A

AU - De Zeeuw, Chris I

AU - van der Spek, Peter J

PY - 2024/5/2

Y1 - 2024/5/2

N2 - Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.

AB - Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.

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DO - 10.1002/bies.202400008

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SN - 0265-9247

VL - 46

SP - e2400008

JO - BioEssays

JF - BioEssays

ER -

Plasticity mechanisms of genetically distinct Purkinje cells

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