Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation

Alida Fe Talento; Katie Dunne; Niamh Murphy; Brian O'Connell; Grace Chan; Eimear Ann Joyce; Ferry Hagen; Jacques F Meis; Ruairi Fahy; Larry Bacon; Elisabeth Vandenberge; Thomas R Rogers

doi:10.1111/myc.12770

Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation

Alida Fe Talento, Katie Dunne, Niamh Murphy, Brian O'Connell, Grace Chan, Eimear Ann Joyce, Ferry Hagen, Jacques F Meis, Ruairi Fahy, Larry Bacon, Elisabeth Vandenberge, Thomas R Rogers

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

9 Citaten (Scopus)

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Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.

Originele taal-2	Engels
Pagina's (van-tot)	570-575
Aantal pagina's	6
Tijdschrift	Mycoses
Volume	61
Nummer van het tijdschrift	8
DOI's	https://doi.org/10.1111/myc.12770
Status	Gepubliceerd - aug. 2018

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10.1111/myc.12770

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title = "Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation",

abstract = "Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.",

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author = "Talento, {Alida Fe} and Katie Dunne and Niamh Murphy and Brian O'Connell and Grace Chan and Joyce, {Eimear Ann} and Ferry Hagen and Meis, {Jacques F} and Ruairi Fahy and Larry Bacon and Elisabeth Vandenberge and Rogers, {Thomas R}",

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AU - Talento, Alida Fe

AU - Dunne, Katie

AU - Murphy, Niamh

AU - O'Connell, Brian

AU - Chan, Grace

AU - Joyce, Eimear Ann

AU - Hagen, Ferry

AU - Meis, Jacques F

AU - Fahy, Ruairi

AU - Bacon, Larry

AU - Vandenberge, Elisabeth

AU - Rogers, Thomas R

PY - 2018/8

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N2 - Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.

AB - Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence of resistance to first-line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole-resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.

KW - Antifungal Agents/pharmacology

KW - Aspergillus fumigatus/drug effects

KW - Drug Resistance, Fungal

KW - Humans

KW - Influenza, Human/complications

KW - Invasive Pulmonary Aspergillosis/diagnosis

KW - Male

KW - Middle Aged

KW - Stem Cell Transplantation/adverse effects

KW - Transplantation, Homologous/adverse effects

KW - Triazoles/pharmacology

U2 - 10.1111/myc.12770

DO - 10.1111/myc.12770

M3 - Article

C2 - 29570855

SN - 0933-7407

VL - 61

SP - 570

EP - 575

JO - Mycoses

JF - Mycoses

IS - 8

ER -

Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation

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