Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity

TY - JOUR

T1 - Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity

AU - Voerman, Stijn

AU - Urbanus, Bastiaan H A

AU - Schonewille, Martijn

AU - White, Joshua J

AU - De Zeeuw, Chris I

N1 - © 2022. The Author(s).

PY - 2022/12/3

Y1 - 2022/12/3

N2 - Cerebellar learning is expressed as upbound or downbound changes in simple spike activity of Purkinje cell subpopulations, but the underlying mechanism remains enigmatic. By visualizing murine Purkinje cells with different molecular identities, we demonstrate that the potential for induction of long-term depression is prominent in downbound and minimal in the upbound subpopulation. These differential propensities depend on the expression profile, but not on the synaptic inputs, of the individual Purkinje cell involved, highlighting the functional relevance of intrinsic properties for memory formation.

AB - Cerebellar learning is expressed as upbound or downbound changes in simple spike activity of Purkinje cell subpopulations, but the underlying mechanism remains enigmatic. By visualizing murine Purkinje cells with different molecular identities, we demonstrate that the potential for induction of long-term depression is prominent in downbound and minimal in the upbound subpopulation. These differential propensities depend on the expression profile, but not on the synaptic inputs, of the individual Purkinje cell involved, highlighting the functional relevance of intrinsic properties for memory formation.

U2 - 10.1038/s42003-022-04283-y

DO - 10.1038/s42003-022-04283-y

M3 - Article

C2 - 36463347

SN - 2399-3642

VL - 5

SP - 1328

JO - Communications Biology

JF - Communications Biology

IS - 1

ER -