Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species

Mahdi Abastabar, Abdullah M.S. Al-Hatmi, Mohammad Vafaei Moghaddam, G. Sybren De Hoog, Iman Haghani, Seyed Reza Aghili, Tahereh Shokohi, Mohammad Taghi Hedayati, Roshanak Daie Ghazvini, Reza Kachuei, Ali Rezaei-Matehkolaei, Koichi Makimura, Jacques F. Meis, Hamid Badalia

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27 Citaten (Scopus)

Samenvatting

Copyright © 2018 American Society for Microbiology. All Rights Reserved. A collection of clinical (n 47) and environmental (n 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 g/ml, respectively, compared with 0.51 g/ml for micafungin, 0.85 g/ml for efinaconazole, 1.12 g/ml for natamycin, 1.18 g/ml for anidulafungin, 1.31 g/ml for voriconazole, 1.35 g/ml for caspofungin, 1.9 g/ml for amphotericin B, and 4.08 g/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due to Fusarium species.
Originele taal-2Engels
TitelAntimicrobial Agents and Chemotherapy
UitgeverijAmerican Society for Microbiology
ISBN van geprinte versie0066-4804
DOI's
StatusGepubliceerd - 01 mei 2018

Publicatie series

NaamAntimicrobial Agents and Chemotherapy
Volume62

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