Protein tyrosine phosphatases: regulatory mechanisms.

J. den Hertog; A. Ostman; F.D. Bohmer

doi:10.1111/j.1742-4658.2008.06247.x

Protein tyrosine phosphatases: regulatory mechanisms.

J. den Hertog, A. Ostman, F.D. Bohmer

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

102 Citaten (Scopus)

Samenvatting

Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.

Originele taal-2	Engels
Pagina's (van-tot)	831-847
Tijdschrift	FEBS Journal
Volume	275
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1111/j.1742-4658.2008.06247.x
Status	Gepubliceerd - 2008

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10.1111/j.1742-4658.2008.06247.x

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title = "Protein tyrosine phosphatases: regulatory mechanisms.",

abstract = "Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.",

author = "{den Hertog}, J. and A. Ostman and F.D. Bohmer",

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AB - Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.

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DO - 10.1111/j.1742-4658.2008.06247.x

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JO - FEBS Journal

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Protein tyrosine phosphatases: regulatory mechanisms.

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