Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth

W.H.G. Hol; J.A. Van Veen

doi:10.1023/A:1020557000707

Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth

W.H.G. Hol, J.A. Van Veen

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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We investigated the growth-reducing effects of pyrrolizidine alkaloids (PAs) from Senecio jacobaea on nine plant-associated fungi (five strains of Fusarium oxysporum, two of F. sambucinum, and two of Trichoderma sp). Fungal growth was monitored on water agar media containing different concentrations of monocrotaline, retrorsine, or a purified extract of PAs from S. jacobaea. The growth rate of six strains was inhibited by PAs at the highest test concentration (3.33 mM), with the magnitude of the inhibition (7-35%) being dependent upon the specific fungus-PA interaction. In general, the PA extract caused the largest inhibition. However, the fungi isolated from S. jacobaea were positively affected by the PA extract (7-9%). Retrorsine N oxide was as effective as retrorsine in its inhibition of mycelium growth. [KEYWORDS: Senecio jacobaea, pyrrolizidine alkaloids, anti fungal activity, retrorsine, N oxide, monocrotaline]

Originele taal-2	Engels
Pagina's (van-tot)	1763-1772
Tijdschrift	Journal of Chemical Ecology
Volume	28
Nummer van het tijdschrift	9
DOI's	https://doi.org/10.1023/A:1020557000707
Status	Gepubliceerd - 2002

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title = "Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth",

abstract = "We investigated the growth-reducing effects of pyrrolizidine alkaloids (PAs) from Senecio jacobaea on nine plant-associated fungi (five strains of Fusarium oxysporum, two of F. sambucinum, and two of Trichoderma sp). Fungal growth was monitored on water agar media containing different concentrations of monocrotaline, retrorsine, or a purified extract of PAs from S. jacobaea. The growth rate of six strains was inhibited by PAs at the highest test concentration (3.33 mM), with the magnitude of the inhibition (7-35%) being dependent upon the specific fungus-PA interaction. In general, the PA extract caused the largest inhibition. However, the fungi isolated from S. jacobaea were positively affected by the PA extract (7-9%). Retrorsine N oxide was as effective as retrorsine in its inhibition of mycelium growth. [KEYWORDS: Senecio jacobaea, pyrrolizidine alkaloids, anti fungal activity, retrorsine, N oxide, monocrotaline]",

author = "W.H.G. Hol and {Van Veen}, J.A.",

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AU - Van Veen, J.A.

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N2 - We investigated the growth-reducing effects of pyrrolizidine alkaloids (PAs) from Senecio jacobaea on nine plant-associated fungi (five strains of Fusarium oxysporum, two of F. sambucinum, and two of Trichoderma sp). Fungal growth was monitored on water agar media containing different concentrations of monocrotaline, retrorsine, or a purified extract of PAs from S. jacobaea. The growth rate of six strains was inhibited by PAs at the highest test concentration (3.33 mM), with the magnitude of the inhibition (7-35%) being dependent upon the specific fungus-PA interaction. In general, the PA extract caused the largest inhibition. However, the fungi isolated from S. jacobaea were positively affected by the PA extract (7-9%). Retrorsine N oxide was as effective as retrorsine in its inhibition of mycelium growth. [KEYWORDS: Senecio jacobaea, pyrrolizidine alkaloids, anti fungal activity, retrorsine, N oxide, monocrotaline]

AB - We investigated the growth-reducing effects of pyrrolizidine alkaloids (PAs) from Senecio jacobaea on nine plant-associated fungi (five strains of Fusarium oxysporum, two of F. sambucinum, and two of Trichoderma sp). Fungal growth was monitored on water agar media containing different concentrations of monocrotaline, retrorsine, or a purified extract of PAs from S. jacobaea. The growth rate of six strains was inhibited by PAs at the highest test concentration (3.33 mM), with the magnitude of the inhibition (7-35%) being dependent upon the specific fungus-PA interaction. In general, the PA extract caused the largest inhibition. However, the fungi isolated from S. jacobaea were positively affected by the PA extract (7-9%). Retrorsine N oxide was as effective as retrorsine in its inhibition of mycelium growth. [KEYWORDS: Senecio jacobaea, pyrrolizidine alkaloids, anti fungal activity, retrorsine, N oxide, monocrotaline]

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Pyrrolizidine alkaloids from Senecio jacobaea affect fungal growth

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