Questioning the cerebellar doctrine

TY - JOUR

T1 - Questioning the cerebellar doctrine

AU - Galliano, Elisa

AU - De Zeeuw, Chris I

N1 - © 2014 Elsevier B.V. All rights reserved.

PY - 2014

Y1 - 2014

N2 - The basic principles of cerebellar function were originally described by Flourens, Cajal, and Marr/Albus/Ito, and they constitute the pillars of what can be considered to be the classic cerebellar doctrine. In their concepts, the main cerebellar function is to control motor behavior, Purkinje cells are the only cortical neuron receiving and integrating inputs from climbing fiber and mossy-parallel fiber pathways, and plastic modification at the parallel fiber synapses onto Purkinje cells constitutes the substrate of motor learning. Yet, because of recent technical advances and new angles of investigation, all pillars of the cerebellar doctrine now face regular re-examination. In this review, after summarizing the classic concepts and recent disputes, we attempt to synthesize an integrated view and propose a revisited version of the cerebellar doctrine.

AB - The basic principles of cerebellar function were originally described by Flourens, Cajal, and Marr/Albus/Ito, and they constitute the pillars of what can be considered to be the classic cerebellar doctrine. In their concepts, the main cerebellar function is to control motor behavior, Purkinje cells are the only cortical neuron receiving and integrating inputs from climbing fiber and mossy-parallel fiber pathways, and plastic modification at the parallel fiber synapses onto Purkinje cells constitutes the substrate of motor learning. Yet, because of recent technical advances and new angles of investigation, all pillars of the cerebellar doctrine now face regular re-examination. In this review, after summarizing the classic concepts and recent disputes, we attempt to synthesize an integrated view and propose a revisited version of the cerebellar doctrine.

U2 - 10.1016/B978-0-444-63356-9.00003-0

DO - 10.1016/B978-0-444-63356-9.00003-0

M3 - Article

C2 - 24916289

SN - 0079-6123

VL - 210

SP - 59

EP - 77

JO - Progress in Brain Research

JF - Progress in Brain Research

ER -