Reduced numbers of corticotropin-releasing hormone neurons in narcolepsy type 1

TY - JOUR

T1 - Reduced numbers of corticotropin-releasing hormone neurons in narcolepsy type 1

AU - Shan, Ling

AU - Balesar, Rawien

AU - Swaab, Dick F

AU - Lammers, Gert Jan

AU - Fronczek, Rolf

N1 - This article is protected by copyright. All rights reserved.

PY - 2022/1

Y1 - 2022/1

N2 - Narcolepsy type 1 (NT1) is a chronic sleep disorder correlated with loss of hypocretin(orexin). In NT1 post-mortem brains, we observed 88% reduction in corticotropin-releasing hormone (CRH)-positive neurons in the paraventricular nucleus (PVN) and significantly less CRH-positive fibers in the median eminence, while CRH-neurons in the locus coeruleus and thalamus, and other PVN neuronal populations were spared: i.e. vasopressin, oxytocin, tyrosine hydroxylase and thyrotropin releasing hormone-expressing neurons. Other hypothalamic cell groups, i.e. the suprachiasmatic, ventrolateral preoptic, infundibular and supraoptic nuclei and nucleus basalis of Meynert were unaffected. The surprising selective decrease in CRH-neurons provide novel targets for diagnostics and therapeutic interventions. This article is protected by copyright. All rights reserved.

AB - Narcolepsy type 1 (NT1) is a chronic sleep disorder correlated with loss of hypocretin(orexin). In NT1 post-mortem brains, we observed 88% reduction in corticotropin-releasing hormone (CRH)-positive neurons in the paraventricular nucleus (PVN) and significantly less CRH-positive fibers in the median eminence, while CRH-neurons in the locus coeruleus and thalamus, and other PVN neuronal populations were spared: i.e. vasopressin, oxytocin, tyrosine hydroxylase and thyrotropin releasing hormone-expressing neurons. Other hypothalamic cell groups, i.e. the suprachiasmatic, ventrolateral preoptic, infundibular and supraoptic nuclei and nucleus basalis of Meynert were unaffected. The surprising selective decrease in CRH-neurons provide novel targets for diagnostics and therapeutic interventions. This article is protected by copyright. All rights reserved.

U2 - 10.1002/ana.26300

DO - 10.1002/ana.26300

M3 - Article

C2 - 34981555

SN - 0364-5134

VL - 91

SP - 282

EP - 288

JO - Annals of Neurology

JF - Annals of Neurology

ER -