Renal transplant patient survives a donor-derived abdominal invasive mucormycosis (Lichtheimia ramosa)

TY - JOUR

T1 - Renal transplant patient survives a donor-derived abdominal invasive mucormycosis (Lichtheimia ramosa)

AU - Spithoven, E M

AU - Bruns, A H W

AU - Petri, B J

AU - Haas, P J

AU - Nguyen, T Q

AU - Hagen, F

AU - van Zuilen, A D

N1 - © 2020 Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Mucormycosis is a life-threatening invasive fungal infection, most commonly described in severely immunocompromised patients. It is characterized by rapid invasive growth of the fungus and often with fatal outcome. We report a case of a renal transplant recipient diagnosed with a donor-derived invasive mucormycosis. In this patient, we used a step-wise approach of withdrawal of immunosuppressants, antifungal induction therapy, extensive surgical debridement of all (potentially) infected tissue, abdominal irrigation of liposomal amphotericin B and interferon gamma. Due to rapid diagnosis and intensive therapy the patient survived.

AB - Mucormycosis is a life-threatening invasive fungal infection, most commonly described in severely immunocompromised patients. It is characterized by rapid invasive growth of the fungus and often with fatal outcome. We report a case of a renal transplant recipient diagnosed with a donor-derived invasive mucormycosis. In this patient, we used a step-wise approach of withdrawal of immunosuppressants, antifungal induction therapy, extensive surgical debridement of all (potentially) infected tissue, abdominal irrigation of liposomal amphotericin B and interferon gamma. Due to rapid diagnosis and intensive therapy the patient survived.

U2 - 10.1016/j.mmcr.2020.10.002

DO - 10.1016/j.mmcr.2020.10.002

M3 - Article

C2 - 33145152

SN - 2211-7539

VL - 30

SP - 39

EP - 42

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

ER -