Repairing organs: lessons from intestine and liver

Helmuth Gehart; Hans Clevers

doi:10.1016/j.tig.2015.04.005

Repairing organs: lessons from intestine and liver

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

26 Citaten (Scopus)

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The concept of organ regeneration has fascinated humanity from ancient mythology to modern science fiction. Recent advances offer the potential to soon bring such technology within the grasp of clinical medicine. Rapidly expanding insights into the intrinsic repair processes of the intestine and liver have uncovered significant plasticity in epithelial tissues. Harnessing this knowledge, researchers have recently created culture systems that enable the expansion of stem cells into transplantable tissue in vitro. Here we discuss how the growing tool set of stem cell biology can bring organ repair from fictitious narrative to medical practice.

Originele taal-2	Engels
Tijdschrift	Trends in Genetics
DOI's	https://doi.org/10.1016/j.tig.2015.04.005
Status	Gepubliceerd - 16 mei 2015

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title = "Repairing organs: lessons from intestine and liver",

abstract = "The concept of organ regeneration has fascinated humanity from ancient mythology to modern science fiction. Recent advances offer the potential to soon bring such technology within the grasp of clinical medicine. Rapidly expanding insights into the intrinsic repair processes of the intestine and liver have uncovered significant plasticity in epithelial tissues. Harnessing this knowledge, researchers have recently created culture systems that enable the expansion of stem cells into transplantable tissue in vitro. Here we discuss how the growing tool set of stem cell biology can bring organ repair from fictitious narrative to medical practice.",

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Repairing organs: lessons from intestine and liver

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