Reparative inflammation takes charge of tissue regeneration

TY - JOUR

T1 - Reparative inflammation takes charge of tissue regeneration

AU - Karin, Michael

AU - Clevers, Hans

PY - 2016/1/21

Y1 - 2016/1/21

N2 - Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.

AB - Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.

KW - Animals

KW - Cytokines

KW - Drosophila melanogaster

KW - Humans

KW - Inflammation

KW - Microbiota

KW - Regeneration

KW - Signal Transduction

KW - Therapeutics

KW - Wound Healing

U2 - 10.1038/nature17039

DO - 10.1038/nature17039

M3 - Article

C2 - 26791721

SN - 0028-0836

VL - 529

SP - 307

EP - 315

JO - Nature

JF - Nature

IS - 7586

ER -