Reuniting philosophy and science to advance cancer research

Thomas Pradeu; Bertrand Daignan-Fornier; Andrew Ewald; Pierre-Luc Germain; Samir Okasha; Anya Plutynski; Sébastien Benzekry; Marta Bertolaso; Mina Bissell; Joel S Brown; Benjamin Chin-Yee; Ian Chin-Yee; Hans Clevers; Laurent Cognet; Marie Darrason; Emmanuel Farge; Jean Feunteun; Jérôme Galon; Elodie Giroux; Sara Green; Fridolin Gross; Fanny Jaulin; Rob Knight; Ezio Laconi; Nicolas Larmonier; Carlo Maley; Alberto Mantovani; Violaine Moreau; Pierre Nassoy; Elena Rondeau; David Santamaria; Catherine M Sawai; Andrei Seluanov; Gregory D Sepich-Poore; Vanja Sisirak; Eric Solary; Sarah Yvonnet; Lucie Laplane

doi:10.1111/brv.12971

Reuniting philosophy and science to advance cancer research

Thomas Pradeu, Bertrand Daignan-Fornier, Andrew Ewald, Pierre-Luc Germain, Samir Okasha, Anya Plutynski, Sébastien Benzekry, Marta Bertolaso, Mina Bissell, Joel S Brown, Benjamin Chin-Yee, Ian Chin-Yee, Hans Clevers, Laurent Cognet, Marie Darrason, Emmanuel Farge, Jean Feunteun, Jérôme Galon, Elodie Giroux, Sara GreenFridolin Gross, Fanny Jaulin, Rob Knight, Ezio Laconi, Nicolas Larmonier, Carlo Maley, Alberto Mantovani, Violaine Moreau, Pierre Nassoy, Elena Rondeau, David Santamaria, Catherine M Sawai, Andrei Seluanov, Gregory D Sepich-Poore, Vanja Sisirak, Eric Solary, Sarah Yvonnet, Lucie Laplane

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

9 Citaten (Scopus)

Samenvatting

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.

Originele taal-2	Engels
Pagina's (van-tot)	1668-1686
Aantal pagina's	19
Tijdschrift	Biological Reviews of the Cambridge Philosophical Society
Volume	98
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1111/brv.12971
Status	Gepubliceerd - okt. 2023

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10.1111/brv.12971

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Pradeu, T., Daignan-Fornier, B., Ewald, A., Germain, P.-L., Okasha, S., Plutynski, A., Benzekry, S., Bertolaso, M., Bissell, M., Brown, J. S., Chin-Yee, B., Chin-Yee, I., Clevers, H., Cognet, L., Darrason, M., Farge, E., Feunteun, J., Galon, J., Giroux, E., ... Laplane, L. (2023). Reuniting philosophy and science to advance cancer research. Biological Reviews of the Cambridge Philosophical Society, 98(5), 1668-1686. https://doi.org/10.1111/brv.12971

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title = "Reuniting philosophy and science to advance cancer research",

abstract = "Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.",

keywords = "Philosophy, Research, Interdisciplinary Studies, Neoplasms",

author = "Thomas Pradeu and Bertrand Daignan-Fornier and Andrew Ewald and Pierre-Luc Germain and Samir Okasha and Anya Plutynski and S{\'e}bastien Benzekry and Marta Bertolaso and Mina Bissell and Brown, {Joel S} and Benjamin Chin-Yee and Ian Chin-Yee and Hans Clevers and Laurent Cognet and Marie Darrason and Emmanuel Farge and Jean Feunteun and J{\'e}r{\^o}me Galon and Elodie Giroux and Sara Green and Fridolin Gross and Fanny Jaulin and Rob Knight and Ezio Laconi and Nicolas Larmonier and Carlo Maley and Alberto Mantovani and Violaine Moreau and Pierre Nassoy and Elena Rondeau and David Santamaria and Sawai, {Catherine M} and Andrei Seluanov and Sepich-Poore, {Gregory D} and Vanja Sisirak and Eric Solary and Sarah Yvonnet and Lucie Laplane",

note = "{\textcopyright} 2023 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.",

year = "2023",

month = oct,

doi = "10.1111/brv.12971",

language = "English",

volume = "98",

pages = "1668--1686",

journal = "Biological Reviews of the Cambridge Philosophical Society",

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Pradeu, T, Daignan-Fornier, B, Ewald, A, Germain, P-L, Okasha, S, Plutynski, A, Benzekry, S, Bertolaso, M, Bissell, M, Brown, JS, Chin-Yee, B, Chin-Yee, I, Clevers, H, Cognet, L, Darrason, M, Farge, E, Feunteun, J, Galon, J, Giroux, E, Green, S, Gross, F, Jaulin, F, Knight, R, Laconi, E, Larmonier, N, Maley, C, Mantovani, A, Moreau, V, Nassoy, P, Rondeau, E, Santamaria, D, Sawai, CM, Seluanov, A, Sepich-Poore, GD, Sisirak, V, Solary, E, Yvonnet, S & Laplane, L 2023, 'Reuniting philosophy and science to advance cancer research', Biological Reviews of the Cambridge Philosophical Society, vol. 98, nr. 5, blz. 1668-1686. https://doi.org/10.1111/brv.12971

TY - JOUR

T1 - Reuniting philosophy and science to advance cancer research

AU - Pradeu, Thomas

AU - Daignan-Fornier, Bertrand

AU - Ewald, Andrew

AU - Germain, Pierre-Luc

AU - Okasha, Samir

AU - Plutynski, Anya

AU - Benzekry, Sébastien

AU - Bertolaso, Marta

AU - Bissell, Mina

AU - Brown, Joel S

AU - Chin-Yee, Benjamin

AU - Chin-Yee, Ian

AU - Clevers, Hans

AU - Cognet, Laurent

AU - Darrason, Marie

AU - Farge, Emmanuel

AU - Feunteun, Jean

AU - Galon, Jérôme

AU - Giroux, Elodie

AU - Green, Sara

AU - Gross, Fridolin

AU - Jaulin, Fanny

AU - Knight, Rob

AU - Laconi, Ezio

AU - Larmonier, Nicolas

AU - Maley, Carlo

AU - Mantovani, Alberto

AU - Moreau, Violaine

AU - Nassoy, Pierre

AU - Rondeau, Elena

AU - Santamaria, David

AU - Sawai, Catherine M

AU - Seluanov, Andrei

AU - Sepich-Poore, Gregory D

AU - Sisirak, Vanja

AU - Solary, Eric

AU - Yvonnet, Sarah

AU - Laplane, Lucie

PY - 2023/10

Y1 - 2023/10

N2 - Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.

AB - Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.

KW - Philosophy

KW - Research

KW - Interdisciplinary Studies

KW - Neoplasms

U2 - 10.1111/brv.12971

DO - 10.1111/brv.12971

M3 - Article

C2 - 37157910

SN - 0006-3231

VL - 98

SP - 1668

EP - 1686

JO - Biological Reviews of the Cambridge Philosophical Society

JF - Biological Reviews of the Cambridge Philosophical Society

IS - 5

ER -

Reuniting philosophy and science to advance cancer research

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