Role of Unipolar Brush Cells in the Vestibulocerebellum

Rachel N. Koops; Cathrin B. Canto; Bin Wu; Martijn Schonewille; Beerend H.J. Winkelman; Chris I. De Zeeuw

doi:10.1007/978-3-031-15070-8_38

Role of Unipolar Brush Cells in the Vestibulocerebellum

Rachel N. Koops^*, Cathrin B. Canto, Bin Wu, Martijn Schonewille, Beerend H.J. Winkelman, Chris I. De Zeeuw

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Hoofdstuk in boek/boekdeel › Hoofdstuk › Wetenschappelijk › peer review

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In all species, unipolar brush cells (UBCs) are most abundant in the vestibulocerebellum. Yet, the role of these excitatory interneurons in the cerebellar input stage during visual and vestibular stimulation remains elusive. Here, we review the main morphological and electrophysiological properties of UBCs in the vestibulocerebellum, and we highlight their potential role in the flocculus during the coordination of compensatory eye movements. We advocate that they are well designed to contribute to expansion coding in the temporal domain, while preserving the identity of sensory and/or oculomotor encoding, so as to facilitate the optimal acquisition of all possible components of movement kinematics.

Originele taal-2	Engels
Titel	Essentials of Cerebellum and Cerebellar Disorders
Subtitel	A Primer For Graduate Students, Second Edition
Uitgeverij	Springer International Publishing AG
Pagina's	243-258
Aantal pagina's	16
ISBN van elektronische versie	9783031150708
ISBN van geprinte versie	9783031150692
DOI's	https://doi.org/10.1007/978-3-031-15070-8_38
Status	Gepubliceerd - 01 jan. 2023

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10.1007/978-3-031-15070-8_38

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abstract = "In all species, unipolar brush cells (UBCs) are most abundant in the vestibulocerebellum. Yet, the role of these excitatory interneurons in the cerebellar input stage during visual and vestibular stimulation remains elusive. Here, we review the main morphological and electrophysiological properties of UBCs in the vestibulocerebellum, and we highlight their potential role in the flocculus during the coordination of compensatory eye movements. We advocate that they are well designed to contribute to expansion coding in the temporal domain, while preserving the identity of sensory and/or oculomotor encoding, so as to facilitate the optimal acquisition of all possible components of movement kinematics.",

keywords = "Expansion coding, Gain control, Glutamate entrapment, Identity preservation, Neural integration, Phase control, Signal delay lines",

author = "Koops, {Rachel N.} and Canto, {Cathrin B.} and Bin Wu and Martijn Schonewille and Winkelman, {Beerend H.J.} and {De Zeeuw}, {Chris I.}",

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AU - Wu, Bin

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AU - Winkelman, Beerend H.J.

AU - De Zeeuw, Chris I.

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Role of Unipolar Brush Cells in the Vestibulocerebellum

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