Scedosporium and Lomentospora: An updated overview of underrated opportunists

Andoni Ramirez-Garcia, Aize Pellon, Aitor Rementeria, Idoia Buldain, Eliana Barreto-Bergter, Rodrigo Rollin-Pinheiro, Jardel Vieira De Meirelles, Mariana Ingrid D.S. Xisto, Stephane Ranque, Vladimir Havlicek, Patrick Vandeputte, Yohann Le Govic, Jean Philippe Bouchara, Sandrine Giraud, Sharon Chen, Johannes Rainer, Ana Alastruey-Izquierdo, Maria Teresa Martin-Gomez, Leyre M. López-Soria, Javier PemanCarsten Schwarz, Anne Bernhardt, Kathrin Tintelnot, Javier Capilla, Adela Martin-Vicente, Jose Cano-Lira, Markus Nagl, Michaela Lackner, Laszlo Irinyi, Wieland Meyer, Sybren De Hoog, Fernando L. Hernando

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

172 Citaten (Scopus)

Samenvatting

Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.
Originele taal-2Engels
Pagina's (van-tot)S102-S125
TijdschriftMedical Mycology
Volume56
DOI's
StatusGepubliceerd - 01 apr. 2018

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