SnapShot: Growing Organoids from Stem Cells

TY - JOUR

T1 - SnapShot

T2 - Growing Organoids from Stem Cells

AU - Sato, Toshiro

AU - Clevers, Hans

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/6/18

Y1 - 2015/6/18

N2 - Tissue stem cells require unique niche microenvironments. In the presence of specific combinations of niche factors, mouse and human epithelial tissues from stomach, small intestine, colon, pancreas duct, and liver bile duct efficiently form stereotypic organoids. The platform of epitheloid organoids can also be employed for in vitro generation of digestive tissue from human pluripotent stem cells. Organoids hold great promise for basic and translational research.

AB - Tissue stem cells require unique niche microenvironments. In the presence of specific combinations of niche factors, mouse and human epithelial tissues from stomach, small intestine, colon, pancreas duct, and liver bile duct efficiently form stereotypic organoids. The platform of epitheloid organoids can also be employed for in vitro generation of digestive tissue from human pluripotent stem cells. Organoids hold great promise for basic and translational research.

U2 - 10.1016/j.cell.2015.06.028

DO - 10.1016/j.cell.2015.06.028

M3 - Article

C2 - 26091044

SN - 0092-8674

VL - 161

SP - 1700-1700.e1

JO - Cell

JF - Cell

IS - 7

ER -