Sorting nexins provide diversity for retromer-dependent trafficking events

TY - JOUR

T1 - Sorting nexins provide diversity for retromer-dependent trafficking events

AU - Cullen, P.J.

AU - Korswagen, H.C.

N1 - Reporting year: 2011

PY - 2012

Y1 - 2012

N2 - Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have fundamental roles in orchestrating cargo sorting through the membranous maze that is the endosomal network. One ancient group of complexes that contain sorting nexins is the retromer. Here we discuss how retromer complexes regulate endosomal sorting, and describe how this is generating exciting new insight into the central role played by endosomal sorting in development and homeostasis of normal tissues.

AB - Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have fundamental roles in orchestrating cargo sorting through the membranous maze that is the endosomal network. One ancient group of complexes that contain sorting nexins is the retromer. Here we discuss how retromer complexes regulate endosomal sorting, and describe how this is generating exciting new insight into the central role played by endosomal sorting in development and homeostasis of normal tissues.

U2 - 10.1038/ncb2374

DO - 10.1038/ncb2374

M3 - Article

SN - 1465-7392

VL - 14

SP - 29

EP - 37

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 1

ER -