Spatial chromatin organization and gene regulation at the nuclear lamina

TY - JOUR

T1 - Spatial chromatin organization and gene regulation at the nuclear lamina

AU - Guerreiro, Isabel

AU - Kind, Jop

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2019/4

Y1 - 2019/4

N2 - The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the genome contacts the NL in broad lamina-associated domains (LADs). Contacts of the NL with the genome are believed to aid the spatial organization of chromosomes and contribute to the regulation of transcription. Here, we will focus on recent insights in the structural organization of the genome at the NL and the role of this organization in the regulation of gene expression.

AB - The nuclear lamina (NL) consists of a thin meshwork of lamins and associated proteins that lines the inner nuclear membrane (INM). In metazoan nuclei, a large proportion of the genome contacts the NL in broad lamina-associated domains (LADs). Contacts of the NL with the genome are believed to aid the spatial organization of chromosomes and contribute to the regulation of transcription. Here, we will focus on recent insights in the structural organization of the genome at the NL and the role of this organization in the regulation of gene expression.

U2 - 10.1016/j.gde.2019.04.008

DO - 10.1016/j.gde.2019.04.008

M3 - Article

C2 - 31112905

SN - 0959-437X

VL - 55

SP - 19

EP - 25

JO - Current Opinion in Genetics & Development

JF - Current Opinion in Genetics & Development

ER -