Strategies for homeostatic stem cell self-renewal in adult tissues

B.D. Simons, H. Clevers

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

381 Citaten (Scopus)


In adult tissues, an exquisite balance exists between stem cell proliferation and the generation of differentiated offspring. Classically, it has been argued that this balance is obtained at the level of a single stem cell, which divides strictly into a new stem cell and a progenitor. However, recent evidence suggests that balance can also be achieved at the level of the stem cell population. Some stem cells might be lost due to differentiation or damage, whereas others divide symmetrically to fill this gap. Here, we consider the general strategies for stem cell self-renewal and review the evidence for stochastic stem cell fate in adult tissues across a range of tissue types and organisms. [KEYWORDS: Adult Stem Cells/ cytology/metabolism, Animals, Cell Division, Cell Lineage, Drosophila/cytology, Humans]
Originele taal-2Engels
Pagina's (van-tot)851-862
Nummer van het tijdschrift6
StatusGepubliceerd - 2011


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