TY - JOUR
T1 - Successful Isavuconazole Salvage Therapy for a Cryptococcus deuterogattii (AFLP6/VGII) Disseminated Infection in a European Immunocompetent Patient
AU - Cuetara, Maria Soledad
AU - Jusdado Ruiz-Capillas, Juan José
AU - Nuñez-Valentin, Maria Pilar
AU - Rodríguez Garcia, Elena
AU - Garcia-Benayas, Elena
AU - Rojo-Amigo, Ricardo
AU - Rodriguez-Gallego, Jose Carlos
AU - Hagen, Ferry
AU - Colom, María Francisca
N1 - © 2021. The Author(s), under exclusive licence to Springer Nature B.V.
PY - 2021/8
Y1 - 2021/8
N2 - Members of the Cryptococcus gattii species complex are notorious causes of cryptococcosis as they often cause severe, life-threatening infections. Here we describe a case of a severe disseminated C. deuterogattii infection in a previously healthy patient who was initially treated with amphotericin B, 5-fluorocytosine and fluconazole, which led to a good neurological response, but the infection in the lungs remained unaltered and was not completely resolved until switching the antifungal therapy to isavuconazole. The infection was likely acquired during a one-month stay at the Azores Islands, Portugal. Environmental sampling did not yield any cryptococcal isolate; therefore, the source of this apparent autochthonous case could not be determined. Molecular typing showed that the cultured C. deuterogattii isolates were closely related to the Vancouver Island outbreak-genotype.
AB - Members of the Cryptococcus gattii species complex are notorious causes of cryptococcosis as they often cause severe, life-threatening infections. Here we describe a case of a severe disseminated C. deuterogattii infection in a previously healthy patient who was initially treated with amphotericin B, 5-fluorocytosine and fluconazole, which led to a good neurological response, but the infection in the lungs remained unaltered and was not completely resolved until switching the antifungal therapy to isavuconazole. The infection was likely acquired during a one-month stay at the Azores Islands, Portugal. Environmental sampling did not yield any cryptococcal isolate; therefore, the source of this apparent autochthonous case could not be determined. Molecular typing showed that the cultured C. deuterogattii isolates were closely related to the Vancouver Island outbreak-genotype.
U2 - 10.1007/s11046-021-00566-w
DO - 10.1007/s11046-021-00566-w
M3 - Article
C2 - 34115285
SN - 0301-486X
VL - 186
SP - 507
EP - 518
JO - Mycopathologia
JF - Mycopathologia
IS - 4
ER -