Surface-based characteristics of the cerebellar cortex visualized with ultra-high field MRI

TY - JOUR

T1 - Surface-based characteristics of the cerebellar cortex visualized with ultra-high field MRI

AU - Boillat, Yohan

AU - Bazin, Pierre-Louis

AU - O'Brien, Kieran

AU - Fartaria, Mário João

AU - Bonnier, Guillaume

AU - Krueger, Gunnar

AU - Van der Zwaag, W.

AU - Granziera, Cristina

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2018

Y1 - 2018

N2 - Although having a relatively homogeneous cytoarchitectonic organization, the cerebellar cortex is a heterogeneous region characterized by different amounts of myelin, iron and protein expression profiles. In this study, we used quantitative T1 and T2* mapping at ultra-high field (7T) MRI to investigate the tissue characteristics of the cerebellar gray matter surface and its layers. Detailed subject-specific surfaces were generated at three different cortical depths and averaged across subjects to create averaged T1 and T2* maps on the cerebellar surface. T1 surfaces showed an alternation of lower and higher T1 values when going from the median to the lateral part of the cerebellar hemispheres. In addition, longer T1 values were observed in the more superficial gray matter layers. T2* maps showed a similar longitudinal pattern, but no change related to the cortical depths. These patterns are possibly due to variations in the level of myelination, iron and zebrin protein expression.

AB - Although having a relatively homogeneous cytoarchitectonic organization, the cerebellar cortex is a heterogeneous region characterized by different amounts of myelin, iron and protein expression profiles. In this study, we used quantitative T1 and T2* mapping at ultra-high field (7T) MRI to investigate the tissue characteristics of the cerebellar gray matter surface and its layers. Detailed subject-specific surfaces were generated at three different cortical depths and averaged across subjects to create averaged T1 and T2* maps on the cerebellar surface. T1 surfaces showed an alternation of lower and higher T1 values when going from the median to the lateral part of the cerebellar hemispheres. In addition, longer T1 values were observed in the more superficial gray matter layers. T2* maps showed a similar longitudinal pattern, but no change related to the cortical depths. These patterns are possibly due to variations in the level of myelination, iron and zebrin protein expression.

KW - Journal Article

U2 - 10.1016/j.neuroimage.2018.01.016

DO - 10.1016/j.neuroimage.2018.01.016

M3 - Article

C2 - 29339314

SN - 1053-8119

VL - 172

SP - 1

EP - 8

JO - NeuroImage

JF - NeuroImage

ER -