T-cell surveillance of the human brain in health and multiple sclerosis

TY - JOUR

T1 - T-cell surveillance of the human brain in health and multiple sclerosis

AU - Smolders, Joost

AU - van Luijn, Marvin M

AU - Hsiao, Cheng-Chih

AU - Hamann, Jörg

N1 - © 2022. The Author(s).

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to the compartmentized organization of the central nervous system (CNS). In recent years, beneficial as well as occasional, detrimental effects of T-cell-targeting drugs in people with early multiple sclerosis (MS) have increased interest in T cells patrolling the CNS. Next to studies focusing on T cells in the cerebrospinal fluid, phenotypic characteristics of T cells located in the perivascular space and the meninges as well as in the parenchyma in MS lesions have been reported. We here summarize the current knowledge about T cells infiltrating the healthy and MS brain and argue that understanding the dynamics of physiological CNS surveillance by T cells is likely to improve the understanding of pathological conditions, such as MS.

AB - Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to the compartmentized organization of the central nervous system (CNS). In recent years, beneficial as well as occasional, detrimental effects of T-cell-targeting drugs in people with early multiple sclerosis (MS) have increased interest in T cells patrolling the CNS. Next to studies focusing on T cells in the cerebrospinal fluid, phenotypic characteristics of T cells located in the perivascular space and the meninges as well as in the parenchyma in MS lesions have been reported. We here summarize the current knowledge about T cells infiltrating the healthy and MS brain and argue that understanding the dynamics of physiological CNS surveillance by T cells is likely to improve the understanding of pathological conditions, such as MS.

U2 - 10.1007/s00281-022-00926-8

DO - 10.1007/s00281-022-00926-8

M3 - Article

C2 - 35364699

SN - 1863-2297

VL - 44

SP - 855

EP - 867

JO - Seminars in immunopathology

JF - Seminars in immunopathology

ER -