The effect of in vitro fertilization on birth rates in western countries

TY - JOUR

T1 - The effect of in vitro fertilization on birth rates in western countries

AU - Habbema, J.D.F.

AU - Eijkemans, M.J.C.

AU - Nargund, G.

AU - Beets, G.C.N.

AU - Leridon, H.

AU - te Velde, E.

N1 - Reporting year: 2009

PY - 2009

Y1 - 2009

N2 - Background: We will assess to what extent in vitro fertilization (IVF) is effective in ncreasing the number of births overall and whether earlier application of IVF will increase this number. Methods: We simulate 100 000 women trying for their first and second child. Natural and IVF pregnancy rates and infertility rates are age-dependent and based on published data. The age at which women start trying for their first child is based on the Netherlands 2002 data.Three cycles of IVF are given during a 12-month period after 1 or 3 years of trying to conceive unsuccessfully. Main outcome measures are live born deliveries and children, both naturally conceived or after IVF, as well as numbers of singletons, twins and triplets, the total fertility rate (TFR) and the number of IVF cycles performed. Results: Full access to IVF after 3 years increases the TFR by 0.08 children. Applying IVF after 1 year leads to an additional TFR increase of 0.04, with double the number of IVF cycles and twin and triplet children, and a shift from naturally conceived children to IVF children. Conclusions: Full access to IVF after 3 years is important. It does increase the TFR. Early availability of IVF would further increase the TFR, but with side-effects and high costs. Key words: in vitro fertilization / assisted reproduction / total fertility rate / multiple pregnancies / IVF policy

AB - Background: We will assess to what extent in vitro fertilization (IVF) is effective in ncreasing the number of births overall and whether earlier application of IVF will increase this number. Methods: We simulate 100 000 women trying for their first and second child. Natural and IVF pregnancy rates and infertility rates are age-dependent and based on published data. The age at which women start trying for their first child is based on the Netherlands 2002 data.Three cycles of IVF are given during a 12-month period after 1 or 3 years of trying to conceive unsuccessfully. Main outcome measures are live born deliveries and children, both naturally conceived or after IVF, as well as numbers of singletons, twins and triplets, the total fertility rate (TFR) and the number of IVF cycles performed. Results: Full access to IVF after 3 years increases the TFR by 0.08 children. Applying IVF after 1 year leads to an additional TFR increase of 0.04, with double the number of IVF cycles and twin and triplet children, and a shift from naturally conceived children to IVF children. Conclusions: Full access to IVF after 3 years is important. It does increase the TFR. Early availability of IVF would further increase the TFR, but with side-effects and high costs. Key words: in vitro fertilization / assisted reproduction / total fertility rate / multiple pregnancies / IVF policy

U2 - 10.1093/humrep/dep004

DO - 10.1093/humrep/dep004

M3 - Article

SN - 0268-1161

VL - 24

SP - 1414

EP - 1419

JO - Human Reproduction

JF - Human Reproduction

IS - 6

ER -