The emerging role of retromer in neuroprotection

TY - JOUR

T1 - The emerging role of retromer in neuroprotection

AU - McMillan, Kirsty J

AU - Korswagen, Hendrick C

AU - Cullen, Peter J

N1 - Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2017/8

Y1 - 2017/8

N2 - Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.

AB - Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.

KW - Animals

KW - Cell-Matrix Junctions

KW - Endosomal Sorting Complexes Required for Transport

KW - Eukaryotic Cells

KW - Humans

KW - Neuroprotection

KW - Parkinson Disease

KW - Protein Transport

KW - Proteolysis

KW - Journal Article

KW - Review

U2 - 10.1016/j.ceb.2017.02.004

DO - 10.1016/j.ceb.2017.02.004

M3 - Article

C2 - 28399507

SN - 0955-0674

VL - 47

SP - 72

EP - 82

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

ER -