The Fitness of Beta-Lactamase Mutants Depends Nonlinearly on Resistance Level at Sublethal Antibiotic Concentrations

Keyphrases

• Antibiotics 100%
• Resistance Level 100%
• β-lactamase 100%
• Fitness Landscape 80%
• Selective Advantage 60%
• High Resistance 60%
• Cefepime 60%
• Resistant Genotypes 40%
• Structured Environments 40%
• Unstructured Environment 40%
• Sub-inhibitory Concentration 40%
• Bacterial Population 20%
• Evolutionary Process 20%
• Genotype 20%
• Antibiotic Resistance 20%
• Susceptible Genotype 20%
• Spatial Structure 20%
• Fitness Evaluation 20%
• Fitness Advantage 20%
• Competition Experiments 20%
• Enhanced Resistance 20%
• Complete Set 20%
• Lethal Concentration 20%
• Filamentation 20%
• Direct Fitness 20%
• Relative Fitness 20%
• Adaptive Evolution 20%
• Evolution Path 20%
• Antibiotic Susceptible 20%
• Antibiotic Resistance Evolution 20%
• Indirect Measurement 20%
• Genotype Space 20%
• Antibiotic Concentration 20%
• Resistance mutant 20%
• Fitness Testing 20%
• Competitive Fitness 20%
• Evolution by Natural Selection 20%
• Antibiotic Resistant 20%
• Fitness Benefits 20%
• Degrading Enzymes 20%
• Specified Condition 20%
• Single-point mutation 20%

Immunology and Microbiology

• Antimicrobial Agent 100%
• Evolution 44%
• Antibiotic Resistance 22%
• Bacterial Population 11%
• Natural Selection 11%
• Filamentation 11%