The frontier of live tissue imaging across space and time

Qiang Huang, Aliesha Garrett, Shree Bose, Stephanie Blocker, Anne C Rios, Hans Clevers, Xiling Shen

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveBoek/film/artikelrecensieWetenschappelijk

Samenvatting

What you see is what you get-imaging techniques have long been essential for visualization and understanding of tissue development, homeostasis, and regeneration, which are driven by stem cell self-renewal and differentiation. Advances in molecular and tissue modeling techniques in the last decade are providing new imaging modalities to explore tissue heterogeneity and plasticity. Here we describe current state-of-the-art imaging modalities for tissue research at multiple scales, with a focus on explaining key tradeoffs such as spatial resolution, penetration depth, capture time/frequency, and moieties. We explore emerging tissue modeling and molecular tools that improve resolution, specificity, and throughput.

Originele taal-2Engels
Pagina's (van-tot)603-622
Aantal pagina's20
TijdschriftCell Stem Cell
Volume28
Nummer van het tijdschrift4
DOI's
StatusGepubliceerd - 01 apr. 2021

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