The frontier of live tissue imaging across space and time

Qiang Huang; Aliesha Garrett; Shree Bose; Stephanie Blocker; Anne C Rios; Hans Clevers; Xiling Shen

doi:10.1016/j.stem.2021.02.010

The frontier of live tissue imaging across space and time

Qiang Huang, Aliesha Garrett, Shree Bose, Stephanie Blocker, Anne C Rios, Hans Clevers, Xiling Shen

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Boek/film/artikelrecensie › Wetenschappelijk

17 Citaten (Scopus)

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What you see is what you get-imaging techniques have long been essential for visualization and understanding of tissue development, homeostasis, and regeneration, which are driven by stem cell self-renewal and differentiation. Advances in molecular and tissue modeling techniques in the last decade are providing new imaging modalities to explore tissue heterogeneity and plasticity. Here we describe current state-of-the-art imaging modalities for tissue research at multiple scales, with a focus on explaining key tradeoffs such as spatial resolution, penetration depth, capture time/frequency, and moieties. We explore emerging tissue modeling and molecular tools that improve resolution, specificity, and throughput.

Originele taal-2	Engels
Pagina's (van-tot)	603-622
Aantal pagina's	20
Tijdschrift	Cell Stem Cell
Volume	28
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1016/j.stem.2021.02.010
Status	Gepubliceerd - 01 apr. 2021

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10.1016/j.stem.2021.02.010

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abstract = "What you see is what you get-imaging techniques have long been essential for visualization and understanding of tissue development, homeostasis, and regeneration, which are driven by stem cell self-renewal and differentiation. Advances in molecular and tissue modeling techniques in the last decade are providing new imaging modalities to explore tissue heterogeneity and plasticity. Here we describe current state-of-the-art imaging modalities for tissue research at multiple scales, with a focus on explaining key tradeoffs such as spatial resolution, penetration depth, capture time/frequency, and moieties. We explore emerging tissue modeling and molecular tools that improve resolution, specificity, and throughput.",

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AU - Shen, Xiling

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The frontier of live tissue imaging across space and time

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