The metabolic syndrome: a brain disease?

TY - JOUR

T1 - The metabolic syndrome: a brain disease?

AU - Buijs, R.M.

AU - Kreier, F.

N1 - doi: 10.1111/j.1365-2826.2006.01456.x

PY - 2006

Y1 - 2006

N2 - The incidence of obesity with, as consequence, a rise in associated diseases such as diabetes, hypertension and dyslipidemia--the metabolic syndrome--is reaching epidemic proportions in industrialized countries. Here, we provide a hypothesis that the biological clock which normally prepares us each morning for the coming activity period is altered due to a modern life style of low activity during the day and late-night food intake. Furthermore, we review the anatomical evidence supporting the proposal that an unbalanced autonomic nervous system output may lead to the simultaneous occurrence of diabetes type 2, dyslipidemia, hypertension and visceral obesity.

AB - The incidence of obesity with, as consequence, a rise in associated diseases such as diabetes, hypertension and dyslipidemia--the metabolic syndrome--is reaching epidemic proportions in industrialized countries. Here, we provide a hypothesis that the biological clock which normally prepares us each morning for the coming activity period is altered due to a modern life style of low activity during the day and late-night food intake. Furthermore, we review the anatomical evidence supporting the proposal that an unbalanced autonomic nervous system output may lead to the simultaneous occurrence of diabetes type 2, dyslipidemia, hypertension and visceral obesity.

M3 - Article

SN - 0953-8194

VL - 18

SP - 715

EP - 716

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

ER -