Samenvatting
MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.
Originele taal-2 | Engels |
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Pagina's (van-tot) | 217-218 |
Tijdschrift | Nature Genetics |
Volume | 35 |
Nummer van het tijdschrift | 3 |
DOI's | |
Status | Gepubliceerd - 2003 |