The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19

TY - JOUR

T1 - The Organoid Platform

T2 - Promises and Challenges as Tools in the Fight against COVID-19

AU - Geurts, Maarten H

AU - van der Vaart, Jelte

AU - Beumer, Joep

AU - Clevers, Hans

N1 - Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2021/3/9

Y1 - 2021/3/9

N2 - Many pathogenic viruses that affect man display species specificity, limiting the use of animal models. Studying viral biology and identifying potential treatments therefore benefits from the development of in vitro cell systems that closely mimic human physiology. In the current COVID-19 pandemic, rapid scientific insights are of the utmost importance to limit its impact on public health and society. Organoids are emerging as versatile tools to progress the understanding of SARS-CoV-2 biology and to aid in the quest for novel treatments.

AB - Many pathogenic viruses that affect man display species specificity, limiting the use of animal models. Studying viral biology and identifying potential treatments therefore benefits from the development of in vitro cell systems that closely mimic human physiology. In the current COVID-19 pandemic, rapid scientific insights are of the utmost importance to limit its impact on public health and society. Organoids are emerging as versatile tools to progress the understanding of SARS-CoV-2 biology and to aid in the quest for novel treatments.

KW - Animals

KW - COVID-19/virology

KW - Humans

KW - Organoids/virology

KW - Pandemics/prevention & control

KW - SARS-CoV-2/pathogenicity

U2 - 10.1016/j.stemcr.2020.11.009

DO - 10.1016/j.stemcr.2020.11.009

M3 - Book/Film/Article review

C2 - 33691146

SN - 2213-6711

VL - 16

SP - 412

EP - 418

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 3

ER -