The role of birth cohorts in long-term trends in liver cirrhosis mortality across eight European countries.

S. Trias Llimós, M. Bijlsma, F. Janssen

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

143 Downloads (Pure)

Samenvatting

Background and aims

Understanding why inequalities in alcohol-related mortality trends by sex and country exist, is essential for developing health policies. Birth cohort effects, indicative of differences by generation in drinking, have rarely been studied. This study estimated the relative contributions of birth cohorts to liver cirrhosis mortality trends and compared sex- and country-specific cohort patterns across eight European countries.

Design

Time-series analysis of population-level mortality data.

Setting

Austria, Finland, Hungary, Italy, the Netherlands, Poland, Spain and Sweden; 1950-2011.

Participants

National populations aged 15-94.

Measurements

We modelled country- and sex-specific liver cirrhosis mortality (from national vital registers) adjusting for age, period and birth cohort.

Findings

Birth cohorts (adjusted for age and period) made statistically significant contributions to liver cirrhosis mortality in all countries and for both sexes (p-values < 0.001), and more so among women (average contribution to deviance reduction of 38.8%) than among men (17.4%). The observed cohort patterns were statistically different between all but two country pairs (p-values < 0.001). Sex differences existed overall (p-value < 0.001), but not in the majority of countries (p-values > 0.999). Visual inspection of birth cohort patterns reveals birth cohorts at higher risk of liver cirrhosis mortality.

Conclusions

The inclusion of the birth cohort dimension improves the understanding of alcohol-attributable mortality trends in Europe. Birth cohorts at higher risk of liver cirrhosis mortality were born around 1935-1949 in Sweden and Finland, around 1950 in Austria and the Netherlands, and around 1960 or later in Hungary, Italy, Poland and Spain.


Originele taal-2Engels
Pagina's (van-tot)250-258
TijdschriftAddiction
Volume112
Nummer van het tijdschrift2
Vroegere onlinedatum16 sep 2016
DOI's
StatusGepubliceerd - 2017

Vingerafdruk

Duik in de onderzoeksthema's van 'The role of birth cohorts in long-term trends in liver cirrhosis mortality across eight European countries.'. Samen vormen ze een unieke vingerafdruk.

Citeer dit