The role of heterochromatin in 3D genome organization during preimplantation development

Franka J Rang; Jop Kind; Isabel Guerreiro

doi:10.1016/j.celrep.2023.112248

The role of heterochromatin in 3D genome organization during preimplantation development

Franka J Rang, Jop Kind, Isabel Guerreiro

Hubrecht Institute

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

1 Citaat (Scopus)

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During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling concerns the heterochromatin and the spatial organization of the genome. While heterochromatin and genome organization are intricately linked in pluripotent and somatic systems, little is known about their relationship in the totipotent embryo. In this review, we summarize the current knowledge on the reprogramming of both regulatory layers. In addition, we discuss available evidence on their relationship and put this in the context of findings in other systems.

Originele taal-2	Engels
Pagina's (van-tot)	112248
Tijdschrift	Cell Reports
Volume	42
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1016/j.celrep.2023.112248
Status	Gepubliceerd - 25 apr. 2023

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10.1016/j.celrep.2023.112248

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title = "The role of heterochromatin in 3D genome organization during preimplantation development",

abstract = "During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling concerns the heterochromatin and the spatial organization of the genome. While heterochromatin and genome organization are intricately linked in pluripotent and somatic systems, little is known about their relationship in the totipotent embryo. In this review, we summarize the current knowledge on the reprogramming of both regulatory layers. In addition, we discuss available evidence on their relationship and put this in the context of findings in other systems.",

keywords = "Animals, Heterochromatin/genetics, Embryonic Development/genetics, Embryo, Mammalian, Mammals/genetics, Genome, Epigenesis, Genetic",

author = "Rang, {Franka J} and Jop Kind and Isabel Guerreiro",

year = "2023",

month = apr,

day = "25",

doi = "10.1016/j.celrep.2023.112248",

language = "English",

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T1 - The role of heterochromatin in 3D genome organization during preimplantation development

AU - Rang, Franka J

AU - Kind, Jop

AU - Guerreiro, Isabel

PY - 2023/4/25

Y1 - 2023/4/25

N2 - During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling concerns the heterochromatin and the spatial organization of the genome. While heterochromatin and genome organization are intricately linked in pluripotent and somatic systems, little is known about their relationship in the totipotent embryo. In this review, we summarize the current knowledge on the reprogramming of both regulatory layers. In addition, we discuss available evidence on their relationship and put this in the context of findings in other systems.

AB - During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling concerns the heterochromatin and the spatial organization of the genome. While heterochromatin and genome organization are intricately linked in pluripotent and somatic systems, little is known about their relationship in the totipotent embryo. In this review, we summarize the current knowledge on the reprogramming of both regulatory layers. In addition, we discuss available evidence on their relationship and put this in the context of findings in other systems.

KW - Animals

KW - Heterochromatin/genetics

KW - Embryonic Development/genetics

KW - Embryo, Mammalian

KW - Mammals/genetics

KW - Genome

KW - Epigenesis, Genetic

U2 - 10.1016/j.celrep.2023.112248

DO - 10.1016/j.celrep.2023.112248

M3 - Article

C2 - 37059092

SN - 2211-1247

VL - 42

SP - 112248

JO - Cell Reports

JF - Cell Reports

IS - 4

ER -

The role of heterochromatin in 3D genome organization during preimplantation development

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