Topology of mammalian developmental enhancers and their regulatory landscapes

W. de Laat, D. Duboule

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

How a complex animal can arise from a fertilized egg is one of the oldest and most fascinating questions of biology, the answer to which is encoded in the genome. Body shape and organ development, and their integration into a functional organism all depend on the precise expression of genes in space and time. The orchestration of transcription relies mostly on surrounding control sequences such as enhancers, millions of which form complex regulatory landscapes in the non-coding genome. Recent research shows that high-order chromosome structures make an important contribution to enhancer functionality by triggering their physical interactions with target genes.
Originele taal-2Engels
Pagina's (van-tot)499-506
TijdschriftNature
Volume502
Nummer van het tijdschrift7472
DOI's
StatusGepubliceerd - 2013

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