Samenvatting
Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in in vitro disease modeling, personalized cancer therapy and regenerative medicine.
| Originele taal-2 | Engels |
|---|---|
| Pagina's (van-tot) | 968-975 |
| Aantal pagina's | 8 |
| Tijdschrift | Development (Cambridge) |
| Volume | 144 |
| Nummer van het tijdschrift | 6 |
| DOI's | |
| Status | Gepubliceerd - 15 mrt. 2017 |