Translational applications of adult stem cell-derived organoids

Jarno Drost, Hans Clevers

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgaveArtikelWetenschappelijkpeer review

Samenvatting

Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in in vitro disease modeling, personalized cancer therapy and regenerative medicine.

Originele taal-2Engels
Pagina's (van-tot)968-975
Aantal pagina's8
TijdschriftDevelopment (Cambridge)
Volume144
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - 15 mrt 2017

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