TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome

Natalie J Forde; Ahmad S Kanaan; Joanna Widomska; Shanmukha S Padmanabhuni; Ester Nespoli; John Alexander; Juan I Rodriguez Arranz; Siyan Fan; Rayan Houssari; Muhammad S Nawaz; Francesca Rizzo; Luca Pagliaroli; Nuno R Zilhäo; Tamas Aranyi; Csaba Barta; Tobias M Boeckers; Dorret I Boomsma; Wim R Buisman; Jan K Buitelaar; Danielle Cath; Andrea Dietrich; Nicole Driessen; Petros Drineas; Michelle Dunlap; Sarah Gerasch; Jeffrey Glennon; Bastian Hengerer; Odile A van den Heuvel; Cathrine Jespersgaard; Harald E Möller; Kirsten R Müller-Vahl; Thaïra J C Openneer; Geert Poelmans; Petra J W Pouwels; Jeremiah M Scharf; Hreinn Stefansson; Zeynep Tümer; Dick J Veltman; Ysbrand D van der Werf; Pieter J Hoekstra; Andrea Ludolph; Peristera Paschou

doi:10.3389/fnins.2016.00384

TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome

Natalie J Forde, Ahmad S Kanaan, Joanna Widomska, Shanmukha S Padmanabhuni, Ester Nespoli, John Alexander, Juan I Rodriguez Arranz, Siyan Fan, Rayan Houssari, Muhammad S Nawaz, Francesca Rizzo, Luca Pagliaroli, Nuno R Zilhäo, Tamas Aranyi, Csaba Barta, Tobias M Boeckers, Dorret I Boomsma, Wim R Buisman, Jan K Buitelaar, Danielle CathAndrea Dietrich, Nicole Driessen, Petros Drineas, Michelle Dunlap, Sarah Gerasch, Jeffrey Glennon, Bastian Hengerer, Odile A van den Heuvel, Cathrine Jespersgaard, Harald E Möller, Kirsten R Müller-Vahl, Thaïra J C Openneer, Geert Poelmans, Petra J W Pouwels, Jeremiah M Scharf, Hreinn Stefansson, Zeynep Tümer, Dick J Veltman, Ysbrand D van der Werf, Pieter J Hoekstra, Andrea Ludolph, Peristera Paschou

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Gilles de la Tourette Syndrome (GTS) is characterized by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency, and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared etiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No. 316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex etiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications, and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared etiology between GTS, OCD, and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and 12 PhD candidates pursue the project. Here, we aim to share the design of an interdisciplinary project, showcasing the potential of large-scale collaborative efforts in the field of GTS. Our ultimate aims are to elucidate the complex etiology and neurobiological underpinnings of GTS, translate research findings into clinical applications, and establish Pan-European infrastructure for the study of GTS and associated disorders.

Originele taal-2	Engels
Pagina's (van-tot)	384
Tijdschrift	Frontiers in Neuroscience
Volume	10
DOI's	https://doi.org/10.3389/fnins.2016.00384
Status	Gepubliceerd - 2016

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10.3389/fnins.2016.00384

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Forde, N. J., Kanaan, A. S., Widomska, J., Padmanabhuni, S. S., Nespoli, E., Alexander, J., Rodriguez Arranz, J. I., Fan, S., Houssari, R., Nawaz, M. S., Rizzo, F., Pagliaroli, L., Zilhäo, N. R., Aranyi, T., Barta, C., Boeckers, T. M., Boomsma, D. I., Buisman, W. R., Buitelaar, J. K., ... Paschou, P. (2016). TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome. Frontiers in Neuroscience, 10, 384. https://doi.org/10.3389/fnins.2016.00384

@article{916d4d95077e45aba1879be13fb4faf7,

title = "TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome",

abstract = "Gilles de la Tourette Syndrome (GTS) is characterized by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency, and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared etiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No. 316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex etiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications, and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared etiology between GTS, OCD, and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and 12 PhD candidates pursue the project. Here, we aim to share the design of an interdisciplinary project, showcasing the potential of large-scale collaborative efforts in the field of GTS. Our ultimate aims are to elucidate the complex etiology and neurobiological underpinnings of GTS, translate research findings into clinical applications, and establish Pan-European infrastructure for the study of GTS and associated disorders.",

author = "Forde, {Natalie J} and Kanaan, {Ahmad S} and Joanna Widomska and Padmanabhuni, {Shanmukha S} and Ester Nespoli and John Alexander and {Rodriguez Arranz}, {Juan I} and Siyan Fan and Rayan Houssari and Nawaz, {Muhammad S} and Francesca Rizzo and Luca Pagliaroli and Zilh{\"a}o, {Nuno R} and Tamas Aranyi and Csaba Barta and Boeckers, {Tobias M} and Boomsma, {Dorret I} and Buisman, {Wim R} and Buitelaar, {Jan K} and Danielle Cath and Andrea Dietrich and Nicole Driessen and Petros Drineas and Michelle Dunlap and Sarah Gerasch and Jeffrey Glennon and Bastian Hengerer and {van den Heuvel}, {Odile A} and Cathrine Jespersgaard and M{\"o}ller, {Harald E} and M{\"u}ller-Vahl, {Kirsten R} and Openneer, {Tha{\"i}ra J C} and Geert Poelmans and Pouwels, {Petra J W} and Scharf, {Jeremiah M} and Hreinn Stefansson and Zeynep T{\"u}mer and Veltman, {Dick J} and {van der Werf}, {Ysbrand D} and Hoekstra, {Pieter J} and Andrea Ludolph and Peristera Paschou",

year = "2016",

doi = "10.3389/fnins.2016.00384",

language = "English",

volume = "10",

pages = "384",

journal = "Frontiers in Neuroscience",

issn = "1662-4548",

publisher = "Frontiers Media SA",

}

Forde, NJ, Kanaan, AS, Widomska, J, Padmanabhuni, SS, Nespoli, E, Alexander, J, Rodriguez Arranz, JI, Fan, S, Houssari, R, Nawaz, MS, Rizzo, F, Pagliaroli, L, Zilhäo, NR, Aranyi, T, Barta, C, Boeckers, TM, Boomsma, DI, Buisman, WR, Buitelaar, JK, Cath, D, Dietrich, A, Driessen, N, Drineas, P, Dunlap, M, Gerasch, S, Glennon, J, Hengerer, B, van den Heuvel, OA, Jespersgaard, C, Möller, HE, Müller-Vahl, KR, Openneer, TJC, Poelmans, G, Pouwels, PJW, Scharf, JM, Stefansson, H, Tümer, Z, Veltman, DJ, van der Werf, YD, Hoekstra, PJ, Ludolph, A & Paschou, P 2016, 'TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome', Frontiers in Neuroscience, vol. 10, blz. 384. https://doi.org/10.3389/fnins.2016.00384

TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome. / Forde, Natalie J; Kanaan, Ahmad S; Widomska, Joanna et al.
In: Frontiers in Neuroscience, Vol. 10, 2016, blz. 384.

Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review

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T2 - A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome

AU - Forde, Natalie J

AU - Kanaan, Ahmad S

AU - Widomska, Joanna

AU - Padmanabhuni, Shanmukha S

AU - Nespoli, Ester

AU - Alexander, John

AU - Rodriguez Arranz, Juan I

AU - Fan, Siyan

AU - Houssari, Rayan

AU - Nawaz, Muhammad S

AU - Rizzo, Francesca

AU - Pagliaroli, Luca

AU - Zilhäo, Nuno R

AU - Aranyi, Tamas

AU - Barta, Csaba

AU - Boeckers, Tobias M

AU - Boomsma, Dorret I

AU - Buisman, Wim R

AU - Buitelaar, Jan K

AU - Cath, Danielle

AU - Dietrich, Andrea

AU - Driessen, Nicole

AU - Drineas, Petros

AU - Dunlap, Michelle

AU - Gerasch, Sarah

AU - Glennon, Jeffrey

AU - Hengerer, Bastian

AU - van den Heuvel, Odile A

AU - Jespersgaard, Cathrine

AU - Möller, Harald E

AU - Müller-Vahl, Kirsten R

AU - Openneer, Thaïra J C

AU - Poelmans, Geert

AU - Pouwels, Petra J W

AU - Scharf, Jeremiah M

AU - Stefansson, Hreinn

AU - Tümer, Zeynep

AU - Veltman, Dick J

AU - van der Werf, Ysbrand D

AU - Hoekstra, Pieter J

AU - Ludolph, Andrea

AU - Paschou, Peristera

PY - 2016

Y1 - 2016

N2 - Gilles de la Tourette Syndrome (GTS) is characterized by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency, and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared etiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No. 316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex etiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications, and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared etiology between GTS, OCD, and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and 12 PhD candidates pursue the project. Here, we aim to share the design of an interdisciplinary project, showcasing the potential of large-scale collaborative efforts in the field of GTS. Our ultimate aims are to elucidate the complex etiology and neurobiological underpinnings of GTS, translate research findings into clinical applications, and establish Pan-European infrastructure for the study of GTS and associated disorders.

AB - Gilles de la Tourette Syndrome (GTS) is characterized by the presence of multiple motor and phonic tics with a fluctuating course of intensity, frequency, and severity. Up to 90% of patients with GTS present with comorbid conditions, most commonly attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), thus providing an excellent model for the exploration of shared etiology across disorders. TS-EUROTRAIN (FP7-PEOPLE-2012-ITN, Grant Agr.No. 316978) is a Marie Curie Initial Training Network (http://ts-eurotrain.eu) that aims to elucidate the complex etiology of the onset and clinical course of GTS, investigate the neurobiological underpinnings of GTS and related disorders, translate research findings into clinical applications, and establish a pan-European infrastructure for the study of GTS. This includes the challenges of (i) assembling a large genetic database for the evaluation of the genetic architecture with high statistical power; (ii) exploring the role of gene-environment interactions including the effects of epigenetic phenomena; (iii) employing endophenotype-based approaches to understand the shared etiology between GTS, OCD, and ADHD; (iv) establishing a developmental animal model for GTS; (v) gaining new insights into the neurobiological mechanisms of GTS via cross-sectional and longitudinal neuroimaging studies; and (vi) partaking in outreach activities including the dissemination of scientific knowledge about GTS to the public. Fifteen partners from academia and industry and 12 PhD candidates pursue the project. Here, we aim to share the design of an interdisciplinary project, showcasing the potential of large-scale collaborative efforts in the field of GTS. Our ultimate aims are to elucidate the complex etiology and neurobiological underpinnings of GTS, translate research findings into clinical applications, and establish Pan-European infrastructure for the study of GTS and associated disorders.

U2 - 10.3389/fnins.2016.00384

DO - 10.3389/fnins.2016.00384

M3 - Article

C2 - 27601976

SN - 1662-4548

VL - 10

SP - 384

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

ER -

TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome

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