Unconventional secretion: a stress on GRASP

TY - JOUR

T1 - Unconventional secretion: a stress on GRASP

AU - Giuliani, F.

AU - Grieve, A.

AU - Rabouille, C.

N1 - Reporting year: 2011

PY - 2011

Y1 - 2011

N2 - Most proteins follow the classical secretory pathway from the endoplasmic reticulum, via the Golgi, to the plasma membrane or extracellular medium. However, some proteins reach these final destinations by two alternative routes. One sustains the extracellular delivery of cytoplasmic proteins that lack a signal peptide, the other supports the transport of transmembrane proteins to the plasma membrane in a manner that bypasses the Golgi. Here, we highlight the observation that some unconventional secretion events are triggered by cellular stress. Furthermore, one Golgi protein, Golgi Re-Assembly and Stacking Protein (GRASP), has been shown to be essential to both types of unconventional secretion and we discuss ways in which it may support these events in a Golgi-independent manner. [KEYWORDS: Animals, Cell Membrane/metabolism, Endoplasmic Reticulum/metabolism, Golgi Apparatus/metabolism, Humans, Membrane Proteins/ metabolism, Secretory Pathway, Yeasts/cytology/metabolism]

AB - Most proteins follow the classical secretory pathway from the endoplasmic reticulum, via the Golgi, to the plasma membrane or extracellular medium. However, some proteins reach these final destinations by two alternative routes. One sustains the extracellular delivery of cytoplasmic proteins that lack a signal peptide, the other supports the transport of transmembrane proteins to the plasma membrane in a manner that bypasses the Golgi. Here, we highlight the observation that some unconventional secretion events are triggered by cellular stress. Furthermore, one Golgi protein, Golgi Re-Assembly and Stacking Protein (GRASP), has been shown to be essential to both types of unconventional secretion and we discuss ways in which it may support these events in a Golgi-independent manner. [KEYWORDS: Animals, Cell Membrane/metabolism, Endoplasmic Reticulum/metabolism, Golgi Apparatus/metabolism, Humans, Membrane Proteins/ metabolism, Secretory Pathway, Yeasts/cytology/metabolism]

U2 - 10.1016/j.ceb.2011.04.005

DO - 10.1016/j.ceb.2011.04.005

M3 - Article

SN - 0955-0674

VL - 23

SP - 498

EP - 504

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 4

ER -