Use and application of 3D-organoid technology

TY - JOUR

T1 - Use and application of 3D-organoid technology

AU - Artegiani, Benedetta

AU - Clevers, Hans

PY - 2018/8/1

Y1 - 2018/8/1

N2 - The capacity of the 3D-organoid cultures to resemble a near-physiological tissue organization and to mimic - to a certain degree - organ functionality, make organoids an excellent model for applications spanning from basic developmental/stem cell research to personalized medicine. Here, we review key findings achieved through organoid technology, and we discuss applications such as disease - and tumour modelling, correction of genetic mutations and understanding gene - and cell functions. Finally, we discuss future developments in the field.

AB - The capacity of the 3D-organoid cultures to resemble a near-physiological tissue organization and to mimic - to a certain degree - organ functionality, make organoids an excellent model for applications spanning from basic developmental/stem cell research to personalized medicine. Here, we review key findings achieved through organoid technology, and we discuss applications such as disease - and tumour modelling, correction of genetic mutations and understanding gene - and cell functions. Finally, we discuss future developments in the field.

U2 - 10.1093/hmg/ddy187

DO - 10.1093/hmg/ddy187

M3 - Article

C2 - 29796608

SN - 0964-6906

VL - 27

SP - R99-R107

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - R2

ER -